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SLC25A21 Antibody (PACO23449)

SKU:
PACO23449
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • SLC25A21 Antibody PACO23449
  • SLC25A21 Antibody PACO23449
€419

Description

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SLC25A21 Antibody (PACO23449)

The SLC25A21 Antibody (PAC023449) is a specialized tool for studying the SLC25A21 protein, which is involved in mitochondrial function and metabolism regulation. This polyclonal antibody is produced in rabbits and is highly specific for detecting SLC25A21 in human samples. Validated for use in Western blot applications, this antibody binds to the SLC25A21 protein, allowing for accurate detection and analysis in a variety of cell types.SLC25A21, also known as the mitochondrial oxoglutarate carrier, plays a crucial role in cellular energy production and metabolism by transporting metabolites across the inner mitochondrial membrane.

Research on SLC25A21 is essential for understanding mitochondrial function and its impact on cellular processes such as energy production and metabolism regulation. This antibody is an invaluable tool for investigations in areas such as bioenergetics, metabolism, and mitochondrial disorders, providing insights into diseases like cancer, metabolic disorders, and neurodegenerative conditions.

Antibody Name:SLC25A21 Antibody (PACO23449)
Antibody SKU:PACO23449
Size:100ul
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:ELISA:1:2000-1:10000, WB:1:500-1:3000, IHC:1:50-1:100
Species Reactivity:Human, Mouse, Rat
Immunogen:Synthesized peptide derived from internal of human SLC25A21.
Form:Liquid
Storage Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageWestern blot analysis of extracts from HepG2 cells, using SLC25A21 antibody.
Product ImageImmunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue using SLC25A21 antibody.
Background:Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, and citrate.
Synonyms:mgc126570; odc; odc1; oxodicarboxylate carrier; slc25a21
UniProt Protein Function:SLC25A21: Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2- oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, and citrate. Belongs to the mitochondrial carrier family.Protein type: Membrane protein, multi-pass; Transporter; Membrane protein, integral; Mitochondrial; Transporter, SLC familyChromosomal Location of Human Ortholog: 14q11.2Cellular Component: mitochondrial inner membrane; integral to membraneBiological Process: lysine catabolic process; transmembrane transport
UniProt Protein Details:
NCBI Summary:SLC25A21 is a homolog of the S. cerevisiae ODC proteins, mitochondrial carriers that transport C5-C7 oxodicarboxylates across inner mitochondrial membranes. One of the species transported by ODC is 2-oxoadipate, a common intermediate in the catabolism of lysine, tryptophan, and hydroxylysine in mammals. Within mitochondria, 2-oxoadipate is converted into acetyl-CoA.[supplied by OMIM, Apr 2004]
UniProt Code:Q9BQT8
NCBI GenInfo Identifier:283837920
NCBI Gene ID:89874
NCBI Accession:NP_001164641.1
UniProt Secondary Accession:Q9BQT8
UniProt Related Accession:Q9BQT8
Molecular Weight:
NCBI Full Name:mitochondrial 2-oxodicarboxylate carrier isoform 2
NCBI Synonym Full Names:solute carrier family 25 member 21
NCBI Official Symbol:SLC25A21  
NCBI Official Synonym Symbols:ODC; ODC1  
NCBI Protein Information:mitochondrial 2-oxodicarboxylate carrier
UniProt Protein Name:Mitochondrial 2-oxodicarboxylate carrier
UniProt Synonym Protein Names:Solute carrier family 25 member 21
Protein Family:Probable ornithine decarboxylase
UniProt Gene Name:SLC25A21  
UniProt Entry Name:ODC_HUMAN
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