The SLC25A21 Polyclonal Antibody (PACO01200) is a valuable tool for researchers studying SLC25A21, a mitochondrial solute carrier protein involved in the transport of nucleotides and coenzymes. This antibody, generated in rabbits, exhibits high specificity and sensitivity for human samples, making it an ideal choice for Western blot applications. By targeting the SLC25A21 protein, researchers can accurately detect and analyze its expression in various cell types, providing key insights into mitochondrial function and metabolism.
SLC25A21 is essential for maintaining mitochondrial nucleotide balance and energy production, making it a crucial player in cellular metabolism and homeostasis. Dysregulation of SLC25A21 has been linked to metabolic disorders and mitochondrial dysfunction, highlighting its potential as a therapeutic target for conditions such as diabetes, obesity, and neurodegenerative diseases. Investigating the role of SLC25A21 with this antibody can uncover new pathways for intervention and treatment in these disease states.
Antibody Name:
SLC25A21 Antibody
Antibody SKU:
PACO01200
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the Internal region of human ODC.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
SLC25A21; ODC; Mitochondrial 2-oxodicarboxylate carrier; Solute carrier family 25 member 21
UniProt Protein Function:
SLC25A21: Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2- oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, and citrate. Belongs to the mitochondrial carrier family.Protein type: Membrane protein, multi-pass; Transporter; Membrane protein, integral; Mitochondrial; Transporter, SLC familyChromosomal Location of Human Ortholog: 14q11.2Cellular Component: mitochondrial inner membrane; integral to membraneBiological Process: lysine catabolic process; transmembrane transport
UniProt Protein Details:
NCBI Summary:
SLC25A21 is a homolog of the S. cerevisiae ODC proteins, mitochondrial carriers that transport C5-C7 oxodicarboxylates across inner mitochondrial membranes. One of the species transported by ODC is 2-oxoadipate, a common intermediate in the catabolism of lysine, tryptophan, and hydroxylysine in mammals. Within mitochondria, 2-oxoadipate is converted into acetyl-CoA.[supplied by OMIM, Apr 2004]
