The SLC25A10 Polyclonal Antibody (PAC047162) is a valuable tool for researchers studying the SLC25A10 protein, which is involved in the transport of important molecules across the mitochondrial membrane. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.SLC25A10, also known as the dicarboxylate carrier, plays a crucial role in the exchange of dicarboxylates in the mitochondria, a process that is essential for energy production and metabolism. Dysregulation of SLC25A10 has been implicated in various diseases, making it a promising target for research in areas such as metabolic disorders and neurodegenerative diseases.
By enabling the detection and analysis of SLC25A10, this antibody is a valuable tool for studying the function and regulation of this important mitochondrial transporter. Researchers can utilize this antibody to further investigate the role of SLC25A10 in cellular metabolism and disease pathology, ultimately contributing to advancements in the understanding and treatment of relevant medical conditions.
Western blot. All lanes: SLC25A10 antibody at 16µg/ml. Lane 1: Mouse liver tissue. Lane 2: Mouse kidney tissue. Lane 3: HepG2 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 32, 33 kDa. Observed band size: 32, 24 kDa..
Immunohistochemistry of paraffin-embedded human prostate cancer using PACO47162 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human liver tissue using PACO47162 at dilution of 1:100.
Background:
Involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite or thiosulfate across mitochondrial inner membrane.
Synonyms:
Mitochondrial dicarboxylate carrier (Solute carrier family 25 member 10), SLC25A10, DIC
UniProt Protein Function:
SLC25A10: Involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite or thiosulfate across mitochondrial inner membrane. Belongs to the mitochondrial carrier family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Transporter, SLC family; Membrane protein, multi-pass; Transporter; Membrane protein, integral; MitochondrialChromosomal Location of Human Ortholog: 17q25.3Cellular Component: mitochondrial inner membrane; integral to membrane; nucleusMolecular Function: protein binding; dicarboxylic acid transmembrane transporter activityBiological Process: sulfur amino acid metabolic process; dicarboxylic acid transport; sulfur amino acid catabolic process; carbohydrate metabolic process; glucose metabolic process; ion transport; pathogenesis; transmembrane transport; mitochondrial transport; gluconeogenesis
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of a family of proteins that translocate small metabolites across the mitochondrial membrane. The encoded protein exchanges dicarboxylates, such as malate and succinate, for phosphate, sulfate, and other small molecules, thereby providing substrates for metabolic processes including the Krebs cycle and fatty acid synthesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
