The SLC25A10 Polyclonal Antibody (PAC012260) is a valuable tool for researchers studying the SLC25A10 protein, a key player in mitochondrial function. This antibody, produced in rabbits, exhibits high specificity and reactivity towards human samples, making it ideal for use in Western blot applications. By binding to the SLC25A10 protein, this antibody allows for precise detection and analysis in a variety of cell types, making it a valuable asset in research related to mitochondrial biology and metabolic disorders.SLC25A10, also known as the dicarboxylate carrier, plays a crucial role in the transport of dicarboxylates across the inner mitochondrial membrane, contributing to the regulation of cellular metabolism and energy production.
Dysregulation of SLC25A10 has been linked to various metabolic disorders and diseases, making it a promising target for therapeutic interventions. Investigating the function and regulation of SLC25A10 is essential for advancing our understanding of mitochondrial dysfunction and developing novel treatment strategies for related conditions.
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10;SLC25A10;DIC ;
UniProt Protein Function:
SLC25A10: Involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite or thiosulfate across mitochondrial inner membrane. Belongs to the mitochondrial carrier family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Transporter, SLC family; Membrane protein, multi-pass; Transporter; Membrane protein, integral; MitochondrialChromosomal Location of Human Ortholog: 17q25.3Cellular Component: mitochondrial inner membrane; integral to membrane; nucleusMolecular Function: protein binding; dicarboxylic acid transmembrane transporter activityBiological Process: sulfur amino acid metabolic process; dicarboxylic acid transport; sulfur amino acid catabolic process; carbohydrate metabolic process; glucose metabolic process; ion transport; pathogenesis; transmembrane transport; mitochondrial transport; gluconeogenesis
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of a family of proteins that translocate small metabolites across the mitochondrial membrane. The encoded protein exchanges dicarboxylates, such as malate and succinate, for phosphate, sulfate, and other small molecules, thereby providing substrates for metabolic processes including the Krebs cycle and fatty acid synthesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
