The SLC24A3 Polyclonal Antibody (PAC020483) is a valuable tool for research on SLC24A3, a protein involved in ion transport and cellular homeostasis. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By targeting the SLC24A3 protein, this antibody enables researchers to detect and analyze its expression in various cell types, making it a versatile tool for studies in physiology and disease.SLC24A3, also known as a sodium/potassium/calcium exchanger 3, plays a crucial role in maintaining ion balance within cells, impacting processes such as signal transduction and cell signaling.
Dysregulation of SLC24A3 has been linked to various diseases, including cardiac disorders and neurological conditions. Investigating the function of SLC24A3 with this antibody may provide insights into the underlying mechanisms of these pathologies and potential therapeutic targets for intervention.Overall, the SLC24A3 Polyclonal Antibody is an essential resource for researchers exploring the role of SLC24A3 in cellular physiology and disease, offering the specificity and sensitivity needed for accurate detection and analysis of this important protein.
Antibody Name:
SLC24A3 Antibody (PACO20483)
Antibody SKU:
PACO20483
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide of human SLC24A3
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO20483(SLC24A3 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Plasma membrane sodium/calcium exchangers are an important component of intracellular calcium homeostasis and electrical conduction. Potassium-dependent sodium/calcium exchangers such as SLC24A3 are believed to transport 1 intracellular calcium and 1 potassium ion in exchange for 4 extracellular sodium ions.
Synonyms:
solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
UniProt Protein Function:
SLC24A3: Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Belongs to the sodium/potassium/calcium exchanger family. SLC24A subfamily.Protein type: Membrane protein, multi-pass; Transporter, SLC family; Membrane protein, integral; TransporterChromosomal Location of Human Ortholog: 20p13Cellular Component: integral to plasma membrane; plasma membraneMolecular Function: calcium channel activity; calcium ion binding; calcium, potassium:sodium antiporter activity; potassium ion binding; sodium ion bindingBiological Process: cellular calcium ion homeostasis; ion transport
UniProt Protein Details:
NCBI Summary:
Plasma membrane sodium/calcium exchangers are an important component of intracellular calcium homeostasis and electrical conduction. Potassium-dependent sodium/calcium exchangers such as SLC24A3 are believed to transport 1 intracellular calcium and 1 potassium ion in exchange for 4 extracellular sodium ions (Kraev et al., 2001 [PubMed 11294880]).[supplied by OMIM, Mar 2008]
