The SLC24A3 Antibody (PAC004811) is a valuable tool for researchers studying SLC24A3, a sodium/potassium/calcium exchanger protein involved in ion transport and cellular homeostasis. This polyclonal antibody, generated in rabbits, has high specificity for human samples and is optimized for use in Western blot applications. By binding to the SLC24A3 protein, this antibody allows for the detection and analysis of SLC24A3 expression in a variety of cell types, making it an essential tool for investigations in molecular biology and physiology.SLC24A3 plays a crucial role in maintaining ion balance within cells, which is essential for various cellular processes such as signal transduction, neurotransmission, and muscle contraction.
Dysregulation of SLC24A3 function has been linked to diseases such as neurological disorders, cardiovascular diseases, and metabolic disorders. Therefore, understanding the function and regulation of SLC24A3 is key to developing therapeutic strategies for these conditions.Overall, the SLC24A3 Antibody (PAC004811) is a reliable reagent for researchers aiming to explore the molecular mechanisms underlying ion transport and cellular homeostasis. Its high specificity and sensitivity make it a valuable tool for advancing our understanding of SLC24A3 biology and its implications in human health and disease.
Antibody Name:
SLC24A3 Antibody
Antibody SKU:
PACO04811
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the Internal region of human NCKX3.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
SLC24A3; NCKX3; Sodium/potassium/calcium exchanger 3; Na(+)/K(+)/Ca(2+)-exchange protein 3; Solute carrier family 24 member 3
UniProt Protein Function:
SLC24A3: Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Belongs to the sodium/potassium/calcium exchanger family. SLC24A subfamily.Protein type: Membrane protein, multi-pass; Transporter, SLC family; Membrane protein, integral; TransporterChromosomal Location of Human Ortholog: 20p13Cellular Component: integral to plasma membrane; plasma membraneMolecular Function: calcium channel activity; calcium ion binding; calcium, potassium:sodium antiporter activity; potassium ion binding; sodium ion bindingBiological Process: cellular calcium ion homeostasis; ion transport
UniProt Protein Details:
NCBI Summary:
Plasma membrane sodium/calcium exchangers are an important component of intracellular calcium homeostasis and electrical conduction. Potassium-dependent sodium/calcium exchangers such as SLC24A3 are believed to transport 1 intracellular calcium and 1 potassium ion in exchange for 4 extracellular sodium ions (Kraev et al., 2001 [PubMed 11294880]).[supplied by OMIM, Mar 2008]
