The SLC22A8 Polyclonal Antibody (CAB3119) is a vital tool for researchers studying SLC22A8, a membrane protein that plays a key role in drug transport and pharmacokinetics. This antibody, generated in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By targeting the SLC22A8 protein, this antibody allows for the detection and analysis of SLC22A8 expression in various cell types, making it ideal for investigations in pharmacology, toxicology, and drug development studies.
SLC22A8, also known as organic cation transporter 3 (OCT3), is involved in the uptake and excretion of drugs and endogenous compounds in the body. Its importance in drug transport processes highlights its relevance in pharmaceutical research and personalized medicine approaches. By understanding the function and regulation of SLC22A8, researchers can gain insights into drug metabolism, efficacy, and potential drug-drug interactions, leading to the development of more effective and safe therapeutic strategies.
Product Name:
SLC22A8 Rabbit Polyclonal Antibody
SKU:
CAB3119
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 443-542 of human OAT3/SLC22A8 (NP_004245.2).
This gene encodes a protein involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.
Purification Method:
Affinity purification
Gene ID:
9376
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using OAT3/SLC22A8 antibody (CAB3119) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
