The SLC22A5 Polyclonal Antibody (CAB1676) is specifically designed for research involving SLC22A5, a cell membrane transporter protein that plays a crucial role in the transport of carnitine into cells. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the SLC22A5 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential tool for studies in metabolism, cardiovascular health, and genetic disorders related to carnitine deficiency.
SLC22A5, also known as OCTN2, is essential for the uptake of carnitine, a crucial cofactor for fatty acid metabolism. Dysregulation of SLC22A5 function has been linked to various metabolic disorders, including primary carnitine deficiency and carnitine uptake defect, highlighting the importance of studying this transporter protein in understanding these conditions. Research into SLC22A5 can provide insights into potential therapeutic interventions for these disorders, as well as for improving overall metabolic health.
Product Name:
SLC22A5 Rabbit Polyclonal Antibody
SKU:
CAB1676
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 430-529 of human SLC22A5 (NP_003051.1).
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is a plasma integral membrane protein which functions both as an organic cation transporter and as a sodium-dependent high affinity carnitine transporter. The encoded protein is involved in the active cellular uptake of carnitine. Mutations in this gene are the cause of systemic primary carnitine deficiency (CDSP), an autosomal recessive disorder manifested early in life by hypoketotic hypoglycemia and acute metabolic decompensation, and later in life by skeletal myopathy or cardiomyopathy. Alternative splicing of this gene results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
6584
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using SLC22A5 Rabbit pAb (CAB1676) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
