The SLC22A2 Polyclonal Antibody (CAB8453) is a valuable tool for research involving SLC22A2, a cell surface protein involved in the transport of organic cations in the body. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By binding to the SLC22A2 protein, this antibody allows for the detection and analysis of SLC22A2 expression in various cell types, making it ideal for studies in pharmacology and drug transport research.
SLC22A2, also known as organic cation transporter 2 (OCT2), plays a crucial role in the uptake and elimination of various endogenous and exogenous compounds in the body. Its function in drug transport and metabolism makes it a key target for research in pharmacokinetics, drug-drug interactions, and personalized medicine. Understanding the role of SLC22A2 is essential for developing effective therapeutics and improving drug safety and efficacy in clinical settings.
Product Name:
SLC22A2 Rabbit Polyclonal Antibody
SKU:
CAB8453
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 44-140 of human SLC22A2 (NP_003049.2).
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption.
Purification Method:
Affinity purification
Gene ID:
6582
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of rat brain, using SLC22A2 antibody (CAB8453) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
