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SLC22A18 Antibody (PACO01269)

SKU:
PACO01269
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
Frequently bought together:

Description

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SLC22A18 Antibody (PACO01269)

The SLC22A18 Polyclonal Antibody (PACO1269) is a valuable tool for researchers studying SLC22A18, a membrane transporter protein involved in the transport of organic cations. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blotting applications. By binding to the SLC22A18 protein, this antibody enables the detection and analysis of SLC22A18 expression in various cell types, making it an ideal choice for studies in molecular biology and drug transport research.

SLC22A18 plays a crucial role in the uptake and elimination of endogenous and exogenous substances, making it a key player in drug pharmacokinetics and toxicity. Understanding the function of SLC22A18 is essential for the development of therapeutic strategies that target drug transport and metabolism. Research into SLC22A18 may provide valuable insights into drug-drug interactions, drug efficacy, and drug resistance mechanisms, with potential implications for the fields of pharmacology and personalized medicine.

Antibody Name:SLC22A18 Antibody
Antibody SKU:PACO01269
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IF
Recommended Dilutions:WB:1:500-1:2000, IF:1:200-1:1000
Species Reactivity:Human
Immunogen:synthesized peptide derived from the C-terminal region of human ORCTL2.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:SLC22A18; BWR1A; BWSCR1A; HET; IMPT1; ITM; ORCTL2; SLC22A1L; TSSC5; Solute carrier family 22 member 18; Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein; Efflux transporter-like protein; Imprinted multi-membrane-spa
UniProt Protein Function:SLC22A18: May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney. Defects in SLC22A18 are associated with lung cancer (LNCR). LNCR is a common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis. Defects in SLC22A18 are a cause of rhabdomyosarcoma type 1 (RMS1). It is a form of rhabdomyosarcoma, a highly malignant tumor of striated muscle derived from primitive mesenchimal cells and exhibiting differentiation along rhabdomyoblastic lines. Rhabdomyosarcoma is one of the most frequently occurring soft tissue sarcomas and the most common in children. It occurs in four forms: alveolar, pleomorphic, embryonal and botryoidal rhabdomyosarcomas. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.Protein type: Membrane protein, multi-pass; Transporter; Transporter, SLC family; Membrane protein, integralChromosomal Location of Human Ortholog: 11p15.5Cellular Component: membrane; cytoplasm; apical plasma membrane; plasma membrane; integral to membrane; nuclear envelopeMolecular Function: symporter activity; ubiquitin protein ligase binding; drug transporter activityBiological Process: organic cation transport; drug transport; multidrug transport; excretion; transmembrane transportDisease: Lung Cancer; Breast Cancer; Rhabdomyosarcoma, Embryonal, 1
UniProt Protein Details:
NCBI Summary:This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is imprinted, with preferential expression from the maternal allele. Mutations in this gene have been found in Wilms' tumor and lung cancer. This protein may act as a transporter of organic cations, and have a role in the transport of chloroquine and quinidine-related compounds in kidney. Two alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Oct 2010]
UniProt Code:Q96BI1
NCBI GenInfo Identifier:166064062
NCBI Gene ID:5002
NCBI Accession:NP_002546.3
UniProt Secondary Accession:Q96BI1,Q78KK3, Q6AY78
UniProt Related Accession:Q96BI1
Molecular Weight:44,846 Da
NCBI Full Name:solute carrier family 22 member 18
NCBI Synonym Full Names:solute carrier family 22, member 18
NCBI Official Symbol:SLC22A18  
NCBI Official Synonym Symbols:HET; ITM; BWR1A; IMPT1; TSSC5; ORCTL2; BWSCR1A; SLC22A1L; p45-BWR1A  
NCBI Protein Information:solute carrier family 22 member 18; ORCTL-2; efflux transporter-like protein; p45 Beckwith-Wiedemann region 1A; organic cation transporter-like 2; p45-Beckwith-Wiedemann region 1 A; tumor-suppressing STF cDNA 5 protein; organic cation transporter-like pro
UniProt Protein Name:Solute carrier family 22 member 18
UniProt Synonym Protein Names:Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein; Efflux transporter-like protein; Imprinted multi-membrane-spanning polyspecific transporter-related protein 1; Organic cation transporter-like protein 2; ORCTL-2; Solute carrier family 22 member 1-like; Tumor-suppressing STF cDNA 5 protein; Tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein; p45-Beckwith-Wiedemann region 1 A
Protein Family:
UniProt Gene Name:SLC22A18  
UniProt Entry Name:S22AI_HUMAN

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