SLC22A17 Antibody (PACO38366)
- SKU:
- PACO38366
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
SLC22A17 Antibody (PACO38366)
The SLC22A17 Polyclonal Antibody (PAC038366) is a valuable tool for researchers studying SLC22A17, a member of the solute carrier family known to be involved in the transport of organic cations. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the SLC22A17 protein, this antibody enables the detection and analysis of SLC22A17 in a variety of cell types, making it well-suited for studies in the fields of molecular biology and drug transport research.
SLC22A17 plays a crucial role in the transport of endogenous and exogenous compounds across cell membranes, impacting drug absorption, distribution, and excretion. Research on SLC22A17 is essential for understanding its involvement in drug metabolism and its potential as a target for therapeutic interventions. By utilizing the SLC22A17 Polyclonal Antibody, researchers can gain valuable insights into the function and regulation of SLC22A17, leading to advancements in drug development and personalized medicine strategies.
| Antibody Name: | SLC22A17 Antibody (PACO38366) |
| Antibody SKU: | PACO38366 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:100-1:500, IF:1:50-1:500 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Solute carrier family 22 member 17 protein (1-99AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: U87 whole cell lysate. All lanes: SLC22A17 antibody at 4µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 58, 56, 22 kDa. Observed band size: 58 kDa. |
 | Immunofluorescence staining of A549 cells with PACO38366 at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | IHC image of PACO38366 diluted at 1:200 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis. |
| Synonyms: | Solute carrier family 22 member 17 (24p3 receptor) (24p3R) (Brain-type organic cation transporter) (Lipocalin-2 receptor) (Neutrophil gelatinase-associated lipocalin receptor) (NgalR), SLC22A17, BOCT BOIT |
| UniProt Protein Function: | SLC22A17: Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Transporter, SLC family; Membrane protein, integral; Transporter Chromosomal Location of Human Ortholog: 14q11.2 Cellular Component: integral to plasma membrane; vacuolar membrane Molecular Function:transmembrane receptor activity; transmembrane transporter activity Biological Process: cellular iron ion homeostasis; siderophore transport; ion transport; signal transduction; transmembrane transport |
| UniProt Code: | Q8WUG5 |
| NCBI GenInfo Identifier: | 27805426 |
| NCBI Gene ID: | 51310 |
| NCBI Accession: | Q8WUG5.1 |
| UniProt Related Accession: | Q8WUG5 |
| Molecular Weight: | |
| NCBI Full Name: | Solute carrier family 22 member 17 |
| NCBI Synonym Full Names: | solute carrier family 22 member 17 |
| NCBI Official Symbol: | SLC22A17Â Â |
| NCBI Official Synonym Symbols: | BOCT; BOIT; 24p3R; NGALR; hBOIT; NGALR2; NGALR3Â Â |
| NCBI Protein Information: | solute carrier family 22 member 17 |
| UniProt Protein Name: | Solute carrier family 22 member 17 |
| UniProt Synonym Protein Names: | 24p3 receptor; 24p3R; Brain-type organic cation transporter; Lipocalin-2 receptor; Neutrophil gelatinase-associated lipocalin receptor; NgalR |
| UniProt Gene Name: | SLC22A17Â Â |
| UniProt Entry Name: | S22AH_HUMAN |
| Antibodies |
| SLC22A17 Antibody (PACO01781) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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