The SLC22A17 Polyclonal Antibody (PAC018897) is a valuable tool for researchers studying SLC22A17, a member of the solute carrier family of proteins involved in the transport of small molecules across cell membranes. This antibody, generated in rabbits, exhibits high reactivity with human samples and is suitable for use in various applications, including Western blotting.SLC22A17 plays a crucial role in the transport of organic cations, such as drugs and endogenous compounds, across cell membranes, impacting drug uptake, distribution, and elimination in the body. Research into the function and regulation of SLC22A17 is essential for understanding its role in drug transport and metabolism, as well as its potential implications in diseases such as cancer and metabolic disorders.
By using the SLC22A17 Polyclonal Antibody, researchers can accurately detect and analyze SLC22A17 protein expression in different cell types, providing insights into its function and involvement in various physiological processes. This antibody is a valuable tool for studies in pharmacology, toxicology, and drug development, aiding in the advancement of personalized medicine and therapeutic strategies targeting SLC22A17.
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO18897(SLC22A17 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human esophagus cancer tissue, Primary antibody: PACO18897(SLC22A17 Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO18897(SLC22A17 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis.
Synonyms:
solute carrier family 22, member 17
UniProt Protein Function:
SLC22A17: Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. 3 isoforms of the human protein are produced by alternative splicing.
