The SLC20A1 Polyclonal Antibody (CAB4117) is designed for research involving SLC20A1, a cell surface phosphate transporter protein that plays a crucial role in phosphate homeostasis and mineralization. The antibody, raised in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot and immunofluorescence applications. By specifically binding to the SLC20A1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an excellent tool for studies in physiology, metabolism, and bone health.SLC20A1, also known as type III sodium-dependent phosphate transporter 1, is a key player in phosphate transport across cell membranes, influencing cellular processes such as mineralization of bones and teeth.
Dysregulation of SLC20A1 has been linked to conditions like hypophosphatemia and vascular calcification, highlighting its importance in maintaining systemic phosphate balance and preventing pathological mineral deposition. Investigating the function and regulation of SLC20A1 is essential for understanding its role in health and disease, with potential implications for the development of therapeutic strategies targeting phosphate metabolism disorders.
Product Name:
SLC20A1 Rabbit Polyclonal Antibody
SKU:
CAB4117
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 257-356 of human SLC20A1 (NP_005406.3).
The protein encoded by this gene is a sodium-phosphate symporter that absorbs phosphate from interstitial fluid for use in cellular functions such as metabolism, signal transduction, and nucleic acid and lipid synthesis. The encoded protein is also a retroviral receptor, causing human cells to be susceptible to infection by gibbon ape leukemia virus, simian sarcoma-associated virus, feline leukemia virus subgroup B, and 10A1 murine leukemia virus.
Purification Method:
Affinity purification
Gene ID:
6574
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using SLC20A1 antibody (CAB4117) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 15s.
