The SLC1A2 Polyclonal Antibody (CAB0910) is a valuable tool for researchers studying SLC1A2, a protein essential for regulating glutamate levels in the brain. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the SLC1A2 protein, this antibody enables precise detection and analysis in various cell types, making it ideal for studies in neuroscience and brain disorders.SLC1A2, also known as excitatory amino acid transporter 2 (EAAT2), plays a crucial role in maintaining proper glutamate levels in the brain, a key neurotransmitter involved in processes such as memory and learning.
Dysregulation of SLC1A2 has been implicated in various neurological disorders, including epilepsy, Alzheimer's disease, and schizophrenia. Research on SLC1A2 is essential for understanding these conditions and developing targeted therapies to treat them.Overall, the SLC1A2 Polyclonal Antibody (CAB0910) offers researchers a reliable tool for investigating the role of SLC1A2 in brain function and neurological disorders, with the potential to advance our understanding and treatment of these conditions.
Product Name:
EAAT2/SLC1A2 Rabbit Polyclonal Antibody
SKU:
CAB0910
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 474-574 of human EAAT2/EAAT2/SLC1A2 (NP_004162.2).
This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Improper regulation of this gene is thought to be associated with several neurological disorders. Alternatively spliced transcript variants of this gene have been identified.
Purification Method:
Affinity purification
Gene ID:
6506
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Perform microwave antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IF staining protocol.Immunofluorescence analysis of paraffin-embedded mouse brain using EAAT2/SLC1A2 Rabbit pAb (CAB0910) at dilution of 1:200 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
