The SLC1A1 Polyclonal Antibody (CAB2903) is a valuable tool for researchers studying the SLC1A1 protein, which is a member of the solute carrier family involved in the transport of small solutes across cell membranes. This antibody is raised in rabbits and exhibits high reactivity with human samples, making it suitable for use in Western blot applications.SLC1A1 plays a crucial role in neurotransmission by regulating the uptake of excitatory amino acids like glutamate. Dysfunction of SLC1A1 has been linked to neurological disorders such as epilepsy, schizophrenia, and obsessive-compulsive disorder.
By using the SLC1A1 Polyclonal Antibody, researchers can study the expression and localization of SLC1A1 in different cell types, providing insights into its role in normal and pathological conditions.Understanding the function of SLC1A1 is essential for developing therapeutic strategies targeting neurotransmission-related disorders. The SLC1A1 Polyclonal Antibody is an invaluable tool for researchers investigating the biological functions and regulatory mechanisms of SLC1A1, paving the way for potential advancements in the treatment of neurological disorders.
Product Name:
SLC1A1 Rabbit Polyclonal Antibody
SKU:
CAB2903
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 430-524 of human SLC1A1 (NP_004161.4).
This gene encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports aspartate, and mutations in this gene are thought to cause dicarboxylicamino aciduria, also known as glutamate-aspartate transport defect.
Purification Method:
Affinity purification
Gene ID:
6505
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using (CAB2903) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
