The SLC19A1 Polyclonal Antibody (CAB12819) is a valuable tool for researchers studying SLC19A1, a key transporter protein involved in the cellular uptake of folate and antifolate drugs. This polyclonal antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the SLC19A1 protein, this antibody allows for precise detection and analysis in a variety of cell types, making it an essential component in studies related to folate metabolism, drug transport, and therapeutic development.SLC19A1, also known as Reduced Folate Carrier 1 (RFC1), plays a crucial role in mediating the cellular uptake of folates, which are essential for DNA synthesis and cell proliferation.
Dysregulation of SLC19A1 function has been linked to various diseases, including cancer and neurological disorders, highlighting its importance in maintaining cellular health and function. By understanding the mechanisms of SLC19A1 transport activity, researchers can uncover new insights into the role of folate metabolism in disease pathogenesis and potentially identify novel therapeutic targets for intervention.Overall, the SLC19A1 Polyclonal Antibody is a valuable tool for investigating the function and regulation of SLC19A1 in normal physiological processes and disease states. Its high specificity and sensitivity make it an ideal choice for researchers seeking to unravel the complexities of folate transport and its impact on cellular
Product Name:
SLC19A1 Rabbit Polyclonal Antibody
SKU:
CAB12819
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 452-591 of human SLC19A1 (NP_919231.1).
The membrane protein encoded by this gene is a transporter of folate and is involved in the regulation of intracellular concentrations of folate. Three transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
6573
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SLC19A1 Rabbit pAb (CAB12819) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
