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SLC18A1 Antibody (PACO12245)

SKU:
PACO12245
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€459

Description

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SLC18A1 Antibody (PACO12245)

The SLC18A1 Polyclonal Antibody (PACO12245) is a valuable tool for researchers studying SLC18A1, a protein involved in the transport of neurotransmitters in the nervous system. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot analyses. By binding to the SLC18A1 protein, this antibody enables the detection and analysis of SLC18A1 in various cell types, making it ideal for neuroscience and pharmacology research.SLC18A1, also known as vesicular monoamine transporter 1 (VMAT1), plays a crucial role in the storage and release of monoamine neurotransmitters such as dopamine and serotonin.

Dysregulation of SLC18A1 has been implicated in various neurological disorders, including Parkinson's disease and schizophrenia. Therefore, studying the function of SLC18A1 using this antibody may provide valuable insights into the pathophysiology of these conditions and aid in the development of novel therapeutic strategies targeting neurotransmitter transport mechanisms.

Antibody Name:SLC18A1 Antibody (PACO12245)
Antibody SKU:PACO12245
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:
Species Reactivity:Human
Immunogen:Human SLC18A1
Form:Liquid
Storage Buffer:PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method:Antigen Affinity purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:solute carrier family 18 (vesicular monoamine), member 1;SLC18A1;CGAT;VAT1;VMAT1 ;
UniProt Protein Function:SLC18A1: Involved in the vesicular transport of biogenic amines. Belongs to the major facilitator superfamily. Vesicular transporter family.
UniProt Protein Details:

Protein type:Transporter, SLC family; Membrane protein, multi-pass; Membrane protein, integral; Transporter

Chromosomal Location of Human Ortholog: 8p21.3

Cellular Component: endoplasmic reticulum membrane; integral to membrane

Molecular Function:monoamine transmembrane transporter activity; drug transporter activity

Biological Process: neurotransmitter transport; monoamine transport; multidrug transport; transmembrane transport

NCBI Summary:The vesicular monoamine transporter acts to accumulate cytosolic monoamines into vesicles, using the proton gradient maintained across the vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (Peter et al., 1993 [PubMed 7905859]). See also SLC18A2 (MIM 193001).[supplied by OMIM, Mar 2008]
UniProt Code:P54219
NCBI GenInfo Identifier:1722741
NCBI Gene ID:6570
NCBI Accession:P54219.1
UniProt Secondary Accession:P54219,Q9BRE4, E9PDJ5,
UniProt Related Accession:P54219
Molecular Weight:472
NCBI Full Name:Chromaffin granule amine transporter
NCBI Synonym Full Names:solute carrier family 18 (vesicular monoamine transporter), member 1
NCBI Official Symbol:SLC18A1  
NCBI Official Synonym Symbols:CGAT; VAT1; VMAT1  
NCBI Protein Information:chromaffin granule amine transporter; vesicular amine transporter 1; solute carrier family 18 member 1; solute carrier family 18 (vesicular monoamine), member 1
UniProt Protein Name:Chromaffin granule amine transporter
UniProt Synonym Protein Names:Solute carrier family 18 member 1; Vesicular amine transporter 1; VAT1
UniProt Gene Name:SLC18A1  
UniProt Entry Name:VMAT1_HUMAN

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