The SLC17A7 Polyclonal Antibody (CAB12879) is a crucial tool for researchers studying SLC17A7, a protein involved in the transport of ions and small molecules across cell membranes. This antibody, generated in rabbits, exhibits high specificity for human samples and has been validated for use in Western blot applications.SLC17A7, also known as vesicular glutamate transporter 1 (VGLUT1), is essential for the release of glutamate from synaptic vesicles in nerve cells. This process is crucial for neurotransmission and synaptic plasticity, making SLC17A7 a key player in brain function and neurological disorders.
By targeting SLC17A7, researchers can gain insights into the mechanisms underlying glutamate release and neuronal communication. This antibody enables the detection and analysis of SLC17A7 in various cell types, providing valuable information for studies in neurobiology, neurodegenerative diseases, and psychiatric disorders. Understanding the role of SLC17A7 is essential for developing therapeutic strategies targeting the glutamatergic system and improving treatment options for neurological conditions.
Product Name:
SLC17A7 Rabbit Polyclonal Antibody
SKU:
CAB12879
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 461-560 of human SLC17A7 (NP_064705.1).
The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport. The protein shares 82% identity with the differentiation-associated Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na+/Pi cotransporter family.
Purification Method:
Affinity purification
Gene ID:
57030
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of U-87MG cells, using SLC17A7 antibody (CAB12879) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
