The SLC17A4 Polyclonal Antibody (PAC042770) is a valuable tool for researchers studying the SLC17A4 protein, a key player in the transport of ions and small molecules across cellular membranes. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.SLC17A4, also known as sodium-dependent phosphate transporter 2B, is involved in the regulation of phosphate homeostasis in the body. Dysregulation of SLC17A4 has been linked to conditions such as hypophosphatemia and hyperphosphatemia, making it a crucial target for research in nephrology, endocrinology, and bone metabolism.
By using the SLC17A4 Polyclonal Antibody, researchers can detect and analyze the expression of SLC17A4 in various cell types, aiding in the understanding of its role in phosphate transport and its potential implications in disease pathology. This antibody is an essential tool for studies focused on elucidating the molecular mechanisms underlying phosphate homeostasis and developing targeted therapies for related disorders.
Antibody Name:
SLC17A4 Antibody (PACO42770)
Antibody SKU:
PACO42770
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Probable small intestine urate exporter protein (14-57AA)
Immunofluorescent analysis of Hela cells using PACO42770 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Acts as a membrane potential-dependent organic anion transporter, the transport requires a low concentration of chloride ions. May be involved in urate extrusion from the intestinal duct. May recognize hydrophilic anionic drugs such as aspirin, salicylate, and ibuprofen as substrates. Able to actively transport inorganic phosphate into cells via Na(+) cotransport (in vitro).
Synonyms:
Probable small intestine urate exporter (Solute carrier family 17 member 4), SLC17A4
UniProt Protein Function:
Function: May be involved in actively transporting phosphate into cells via Na+ cotransport By similarity.Subcellular location: Membrane; Multi-pass membrane protein Potential. Tissue specificity: Expressed intestine, colon, liver and pancreas. Ref.1Sequence similarities: Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.
UniProt Protein Details:
NCBI Summary:
Phosphate homeostasis is maintained by regulating intake, intestinal absorption, bone deposition and resorption, and renal excretion of phosphate. The central molecule in the control of phosphate excretion from the kidney is the sodium/phosphate cotransporter NPT1 (SLC17A1; MIM 182308), which is located in the renal proximal tubule. NPT1 uses the transmembrane electrochemical potential gradient of sodium to transport phosphate across the cell membrane. SLC17A4 is a similar sodium/phosphate cotransporter in the intestinal mucosa that plays an important role in the absorption of phosphate from the intestine (summary by Shibui et al., 1999 [PubMed 10319585]).[supplied by OMIM, Feb 2011]
