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SLC17A3 Antibody (PACO29920)

SKU:
PACO29920
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • SLC17A3 Antibody PACO29920
  • SLC17A3 Antibody PACO29920
€359

Description

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SLC17A3 Antibody (PACO29920)

The SLC17A3 Antibody (PAC02920) is a polyclonal antibody specifically designed for research involving SLC17A3, a solute carrier protein involved in the transport of inorganic phosphate. This antibody, produced using rabbits as the host species, is highly reactive with human samples and has been validated for use in Western blot applications. By binding to the SLC17A3 protein, this antibody enables accurate detection and analysis in various cell types, making it an essential tool for studies in biochemistry and molecular biology.

SLC17A3, also known as sodium-dependent phosphate transporter 2C, plays a crucial role in cellular phosphate homeostasis by mediating the uptake of phosphate into cells. Aberrant expression or function of SLC17A3 has been implicated in various diseases, including phosphate-related disorders, kidney diseases, and metabolic syndromes. Research into SLC17A3 function is fundamental for understanding the mechanisms underlying these conditions and may lead to the development of targeted therapies for patients in need.

Antibody Name:SLC17A3 Antibody (PACO29920)
Antibody SKU:PACO29920
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, IHC, IF
Recommended Dilutions:ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200
Species Reactivity:Human
Immunogen:Recombinant Human Sodium-dependent phosphate transport protein 4 protein (1-125AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageImmunohistochemistry of paraffin-embedded human tonsil tissue using PACO29920 at dilution of 1:100.
Product ImageImmunofluorescent analysis of Hela cells using PACO29920 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:Isoform 2: voltage-driven, multispecific, organic anion transporter able to transport para-aminohippurate (PAH), estrone sulfate, estradiol-17-beta-glucuronide, bumetanide, and ochratoxin A. Isoform 2 functions as urate efflux transporter on the apical side of renal proximal tubule and is likely to act as an exit path for organic anionic drugs as well as urate in vivo. May be involved in actively transporting phosphate into cells via Na(+) cotransport.
Synonyms:Sodium-dependent phosphate transport protein 4 (Na(+)/PI cotransporter 4) (Sodium/phosphate cotransporter 4) (Solute carrier family 17 member 3), SLC17A3, NPT4
UniProt Protein Function:Function: Isoform 2: voltage-driven, multispecific, organic anion transporter able to transport para-aminohippurate (PAH), estrone sulfate, estradiol-17-beta-glucuronide, bumetanide, and ochratoxin A. Isoform 2 functions as urate efflux transporter on the apical side of renal proximal tubule and is likely to act as an exit path for organic anionic drugs as well as urate in vivo. May be involved in actively transporting phosphate into cells via Na+ cotransport. Ref.7Subcellular location: Isoform 1: Endoplasmic reticulum membrane; Multi-pass membrane protein Ref.6 Ref.7. Isoform 2: Cell membrane; Multi-pass membrane protein Ref.6 Ref.7. Tissue specificity: Expressed in the liver and kidney. It is detected in proximal tubules in renal cortex as well as some tubules and glomeruli, with highest expression at the apical side of proximal tubules (at protein level). Ref.1 Ref.7Polymorphism: Genetic variations in SLC17A3 influence the variance in serum uric acid concentrations and define the serum uric acid concentration quantitative trait locus 4 (UAQTL4) [MIM:612671]. Excess serum accumulation of uric acid can lead to the development of gout, a common disorder characterized by tissue deposition of monosodium urate crystals as a consequence of hyperuricemia.Sequence similarities: Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.Sequence caution: The sequence AAB53423.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
UniProt Protein Details:
NCBI Summary:The protein encoded by this gene is a voltage-driven transporter that excretes intracellular urate and organic anions from the blood into renal tubule cells. Two transcript variants encoding different isoforms have been found for this gene. The longer isoform is a plasma membrane protein with transporter activity while the shorter isoform localizes to the endoplasmic reticulum. [provided by RefSeq, Aug 2012]
UniProt Code:O00476
NCBI GenInfo Identifier:148743791
NCBI Gene ID:10786
NCBI Accession:NP_001091956.1
UniProt Secondary Accession:O00476
UniProt Related Accession:O00476
Molecular Weight:46 kDa
NCBI Full Name:sodium-dependent phosphate transport protein 4 isoform a
NCBI Synonym Full Names:solute carrier family 17 member 3
NCBI Official Symbol:SLC17A3  
NCBI Official Synonym Symbols:NPT4; GOUT4; UAQTL4  
NCBI Protein Information:sodium-dependent phosphate transport protein 4
UniProt Protein Name:Sodium-dependent phosphate transport protein 4
UniProt Synonym Protein Names:Na(+)/PI cotransporter 4; Sodium/phosphate cotransporter 4; Solute carrier family 17 member 3
Protein Family:Sodium-dependent phosphate transport protein
UniProt Gene Name:SLC17A3  
UniProt Entry Name:NPT4_HUMAN
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