SLC16A8 Antibody (PACO51954)
- SKU:
- PACO51954
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
SLC16A8 Antibody (PACO51954)
The SLC16A8 Monoclonal Antibody (PAC051954) is a essential tool for researchers studying SLC16A8, a member of the solute carrier family of proteins that are involved in the transport of molecules across cell membranes. This antibody, developed for use in various research applications, is produced in mice and has been validated for use in Western blotting and immunohistochemistry.SLC16A8, also known as monocarboxylate transporter 3 (MCT3), plays a key role in the transport of monocarboxylic acids, such as lactate and pyruvate, across cell membranes.
Its expression patterns and functions have been implicated in various physiological and pathological processes, including cancer metabolism and metabolic disorders. By targeting SLC16A8, researchers can gain valuable insights into its role in cellular metabolism and potential therapeutic strategies for related conditions.
| Antibody Name: | SLC16A8 Antibody (PACO51954) |
| Antibody SKU: | PACO51954 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Monocarboxylate transporter 3 protein (432-504AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: K562 whole cell lysate, Jurkat whole cell lysate, HepG2 whole cell lysate, Mouse brain tissue. All lanes: SLC16A8 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 53 kDa. Observed band size: 53 kDa.. |
 | Immunofluorescent analysis of A549 cells using PACO51954 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human eye tissue using PACO51954 at dilution of 1:100. |
| Background: | Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acid, derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity). |
| Synonyms: | Monocarboxylate transporter 3 (MCT 3) (Solute carrier family 16 member 8), SLC16A8, MCT3 |
| UniProt Protein Function: | SLC16A8: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. |
| UniProt Protein Details: | Protein type:Transporter, SLC family; Transporter; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 22q12.3-q13.2 Cellular Component: membrane; plasma membrane Molecular Function:lactate transmembrane transporter activity; monocarboxylic acid transmembrane transporter activity Biological Process: lactate transport; leukocyte migration; pyruvate metabolic process |
| NCBI Summary: | SLC16A8 is a member of a family of proton-coupled monocarboxylate transporters that mediate lactate transport across cell membranes (Yoon et al., 1999 [PubMed 10493836]).[supplied by OMIM, Apr 2010] |
| UniProt Code: | O95907 |
| NCBI GenInfo Identifier: | 17433295 |
| NCBI Gene ID: | 23539 |
| NCBI Accession: | O95907.1 |
| UniProt Secondary Accession: | O95907,Q9UBE2, |
| UniProt Related Accession: | O95907 |
| Molecular Weight: | 52,319 Da |
| NCBI Full Name: | Monocarboxylate transporter 3 |
| NCBI Synonym Full Names: | solute carrier family 16 member 8 |
| NCBI Official Symbol: | SLC16A8Â Â |
| NCBI Official Synonym Symbols: | MCT3; REMPÂ Â |
| NCBI Protein Information: | monocarboxylate transporter 3 |
| UniProt Protein Name: | Monocarboxylate transporter 3 |
| UniProt Synonym Protein Names: | Solute carrier family 16 member 8 |
| Protein Family: | Monocarboxylate transporter |
| UniProt Gene Name: | SLC16A8Â Â |
| UniProt Entry Name: | MOT3_HUMAN |
| ELISA Kits |
| Human SLC16A8 ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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