The SLC16A2 Polyclonal Antibody (CAB3636) is intended for use in research involving SLC16A2, a member of the SLC16 gene family known for its role in monocarboxylic acid transport. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.SLC16A2, also referred to as MCT8 (Monocarboxylate transporter 8), is involved in the transport of thyroid hormones and has been linked to conditions such as Allan-Herndon-Dudley syndrome. By targeting the SLC16A2 protein, researchers can study its function in various cell types and explore its potential implications in thyroid hormone transport and related disorders.
The importance of SLC16A2 in thyroid hormone transport highlights its relevance in endocrinology research and the development of treatments for thyroid disorders. This antibody serves as a valuable tool for investigating the role of SLC16A2 in cellular transport mechanisms and may contribute to advancements in thyroid-related therapies.
Product Name:
SLC16A2 Rabbit Polyclonal Antibody
SKU:
CAB3636
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human SLC16A2 (NP_006508.2).
This gene encodes an integral membrane protein that functions as a transporter of thyroid hormone. The encoded protein facilitates the cellular importation of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). This gene is expressed in many tissues and likely plays an important role in the development of the central nervous system. Loss of function mutations in this gene are associated with psychomotor retardation in males while females exhibit no neurological defects and more moderate thyroid-deficient phenotypes. This gene is subject to X-chromosome inactivation. Mutations in this gene are the cause of Allan-Herndon-Dudley syndrome.
Purification Method:
Affinity purification
Gene ID:
6567
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SLC16A2 Rabbit pAb (CAB3636) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
