The SLC16A12 Polyclonal Antibody (PACO55186) is a valuable tool for research involving SLC16A12, a member of the SLC16 gene family known for its involvement in various metabolic pathways. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the SLC16A12 protein, researchers can accurately detect and analyze its expression in different cell types, making it an excellent choice for studies in metabolism and disease research.SLC16A12, also known as monocarboxylate transporter 12, plays a crucial role in transporting metabolites across cell membranes, making it a key player in metabolic processes such as energy production and pH regulation.
Dysregulation of SLC16A12 has been linked to metabolic disorders, making it a promising target for research in diseases like diabetes, obesity, and metabolic syndrome. Understanding the function of SLC16A12 is essential for developing new therapeutic strategies to target metabolic pathways and improve treatment outcomes in these conditions.
Western Blot. Positive WB detected in: Jurkat whole cell lysate, 293 whole cell lysate, Hela whole cell lysate, HepG2 whole cell lysate. All lanes: SLC16A12 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 54 kDa. Observed band size: 54 kDa.
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using PACO55186 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human testis tissue using PACO55186 at dilution of 1:100.
Background:
Proton-linked monocarboxylate transporter that mediates creatine transport across the plasma membrane.
Synonyms:
Monocarboxylate transporter 12 (MCT 12) (Creatine transporter 2) (CRT2) (Solute carrier family 16 member 12), SLC16A12, MCT12
UniProt Protein Function:
SLC16A12: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates. Defects in SLC16A12 are a cause of cataract juvenile with microcornea and glucosuria (CJMG). Renal glucosuria is defined by elevated glucose level in the urine without hyperglycemia and without evidence of morphological renal anomalies. Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.Protein type: Transporter, SLC family; Membrane protein, integral; Membrane protein, multi-pass; TransporterChromosomal Location of Human Ortholog: 10q23.31Cellular Component: integral to plasma membraneMolecular Function: creatine transporter activity; lactate transmembrane transporter activity; symporter activityDisease: Cataract, Juvenile, With Microcornea And Glucosuria
UniProt Protein Details:
NCBI Summary:
This gene encodes a transmembrane transporter that likely plays a role in monocarboxylic acid transport. A mutation in this gene has been associated with juvenile cataracts with microcornea and renal glucosuria. [provided by RefSeq, Mar 2010]
