The SLC16A12 Antibody (PAC020482) is a valuable tool for researchers studying SLC16A12, a member of the solute carrier family known for its role in transporting metabolites across cell membranes. This polyclonal antibody, produced in rabbits, shows high reactivity with human samples and has been validated for Western blot applications. By specifically binding to the SLC16A12 protein, this antibody allows for the detection and analysis of SLC16A12 in various cell types, making it ideal for studies in metabolism, transport biology, and kidney function.
SLC16A12, also known as monocarboxylate transporter 12, is involved in the transport of monocarboxylates, such as lactate and pyruvate, across cell membranes. Its importance in metabolic processes and kidney function makes it a promising target for research in metabolic disorders, kidney diseases, and cancer metabolism. Understanding the function of SLC16A12 is essential for developing therapeutics that target metabolic pathways and transport mechanisms in these disease contexts.
Antibody Name:
SLC16A12 Antibody (PACO20482)
Antibody SKU:
PACO20482
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human SLC16A12
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20482(SLC16A12 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a transmembrane transporter that likely plays a role in monocarboxylic acid, transport. A mutation in this gene has been associated with juvenile cataracts with microcornea and renal glucosuria.
Synonyms:
solute carrier family 16, member 12
UniProt Protein Function:
SLC16A12: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates. Defects in SLC16A12 are a cause of cataract juvenile with microcornea and glucosuria (CJMG). Renal glucosuria is defined by elevated glucose level in the urine without hyperglycemia and without evidence of morphological renal anomalies. Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.Protein type: Transporter, SLC family; Membrane protein, integral; Membrane protein, multi-pass; TransporterChromosomal Location of Human Ortholog: 10q23.31Cellular Component: integral to plasma membraneMolecular Function: creatine transporter activity; lactate transmembrane transporter activity; symporter activityDisease: Cataract, Juvenile, With Microcornea And Glucosuria
UniProt Protein Details:
NCBI Summary:
This gene encodes a transmembrane transporter that likely plays a role in monocarboxylic acid transport. A mutation in this gene has been associated with juvenile cataracts with microcornea and renal glucosuria. [provided by RefSeq, Mar 2010]
