The SLC16A12 Polyclonal Antibody (PAC020481) is a valuable tool for researchers studying SLC16A12, a member of the SLC16 gene family involved in the transport of monocarboxylates such as lactate, pyruvate, and ketone bodies across cell membranes. This antibody, raised in rabbits, has high reactivity with human samples and is validated for use in Western blot applications. By binding to the SLC16A12 protein, the antibody allows for the detection and analysis of SLC16A12 in various cell types, making it ideal for studies in metabolism, cancer, and kidney function research.SLC16A12 plays a crucial role in cellular metabolism by facilitating the transport of key energy substrates across cell membranes.
Dysregulation of SLC16A12 has been implicated in various diseases, including cancer, metabolic disorders, and kidney diseases. Understanding the function and regulation of SLC16A12 is essential for developing targeted therapies and diagnostic tools for these conditions.Overall, the SLC16A12 Polyclonal Antibody provides researchers with a reliable and specific tool for investigating the role of SLC16A12 in various physiological and pathological processes, advancing our understanding of cellular metabolism and disease mechanisms.
Antibody Name:
SLC16A12 Antibody (PACO20481)
Antibody SKU:
PACO20481
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human SLC16A12
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO20481(SLC16A12 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a transmembrane transporter that likely plays a role in monocarboxylic acid, transport. A mutation in this gene has been associated with juvenile cataracts with microcornea and renal glucosuria.
Synonyms:
solute carrier family 16, member 12
UniProt Protein Function:
SLC16A12: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates. Defects in SLC16A12 are a cause of cataract juvenile with microcornea and glucosuria (CJMG). Renal glucosuria is defined by elevated glucose level in the urine without hyperglycemia and without evidence of morphological renal anomalies. Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.Protein type: Transporter, SLC family; Membrane protein, integral; Membrane protein, multi-pass; TransporterChromosomal Location of Human Ortholog: 10q23.31Cellular Component: integral to plasma membraneMolecular Function: creatine transporter activity; lactate transmembrane transporter activity; symporter activityDisease: Cataract, Juvenile, With Microcornea And Glucosuria
UniProt Protein Details:
NCBI Summary:
This gene encodes a transmembrane transporter that likely plays a role in monocarboxylic acid transport. A mutation in this gene has been associated with juvenile cataracts with microcornea and renal glucosuria. [provided by RefSeq, Mar 2010]
