The SLC16A12 Polyclonal Antibody (PAC04182) is a valuable tool for researchers studying SLC16A12, a member of the SLC16 family of transporters known as monocarboxylate transporters. This antibody, produced in rabbits, shows high reactivity with human samples and is validated for Western blot applications. By binding specifically to the SLC16A12 protein, this antibody enables detection and analysis in various cell types, making it an ideal choice for studies in metabolism, cancer research, and related fields.
SLC16A12 is involved in the transport of monocarboxylates such as lactate and pyruvate across cell membranes, playing a crucial role in energy metabolism and pH regulation. Dysregulation of SLC16A12 has been linked to various diseases, including cancer and metabolic disorders, making it an attractive target for therapeutic intervention. Understanding the function and regulation of SLC16A12 is essential for developing treatments that target metabolic pathways and cellular metabolism.
Antibody Name:
SLC16A12 Antibody
Antibody SKU:
PACO04182
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human, Mouse
Immunogen:
synthesized peptide derived from the Internal region of human MCT12.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
SLC16A12; MCT12; Monocarboxylate transporter 12; MCT 12; Solute carrier family 16 member 12
UniProt Protein Function:
SLC16A12: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates. Defects in SLC16A12 are a cause of cataract juvenile with microcornea and glucosuria (CJMG). Renal glucosuria is defined by elevated glucose level in the urine without hyperglycemia and without evidence of morphological renal anomalies. Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.Protein type: Transporter, SLC family; Membrane protein, integral; Membrane protein, multi-pass; TransporterChromosomal Location of Human Ortholog: 10q23.31Cellular Component: integral to plasma membraneMolecular Function: creatine transporter activity; lactate transmembrane transporter activity; symporter activityDisease: Cataract, Juvenile, With Microcornea And Glucosuria
UniProt Protein Details:
NCBI Summary:
This gene encodes a transmembrane transporter that likely plays a role in monocarboxylic acid transport. A mutation in this gene has been associated with juvenile cataracts with microcornea and renal glucosuria. [provided by RefSeq, Mar 2010]
