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SLC13A5 Antibody (PACO50718)

SKU:
PACO50718
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • SLC13A5 Antibody PACO50718
  • SLC13A5 Antibody PACO50718
  • SLC13A5 Antibody PACO50718
€359

Description

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SLC13A5 Antibody (PACO50718)

The SLC13A5 Antibody (PAC050718) is a valuable tool for researchers studying the SLC13A5 protein, which plays a crucial role in cellular transport processes. This polyclonal antibody, raised in rabbits, exhibits high reactivity with human samples and is specifically validated for use in Western blot applications.SLC13A5, also known as the sodium-citrate cotransporter, is involved in the transport of citrate and other molecules across cell membranes. Its function is essential for maintaining cellular metabolism and energy balance, making it a key target for studying metabolic disorders, including obesity and diabetes.

By detecting and analyzing SLC13A5 protein expression in various cell types, this antibody enables researchers to explore the role of SLC13A5 in health and disease.Furthermore, understanding the molecular mechanisms underlying SLC13A5 function could lead to the development of therapeutic strategies for metabolic disorders and related conditions. By utilizing the SLC13A5 Antibody (PAC050718) in their research, scientists can advance our knowledge of cellular transport processes and potentially uncover new therapeutic opportunities in the field of metabolism and metabolic disease.

Antibody Name:SLC13A5 Antibody (PACO50718)
Antibody SKU:PACO50718
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC, IF
Recommended Dilutions:ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200
Species Reactivity:Human, Mouse, Rat
Immunogen:Recombinant Human Solute carrier family 13 member 5 protein (156-204AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageWestern Blot. Positive WB detected in: HepG2 whole cell lysate, Rat liver tissue, Mouse heart tissue. All lanes: SLC13A5 antibody at 2.7µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 64, 59, 62 kDa. Observed band size: 64, 59 kDa..
Product ImageImmunofluorescent analysis of HepG2 cells using PACO50718 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Product ImageImmunohistochemistry of paraffin-embedded human liver tissue using PACO50718 at dilution of 1:100.
Background:High-affinity sodium/citrate cotransporter that mediates citrate entry into cells. The transport process is electrogenic; it is the trivalent form of citrate rather than the divalent form that is recognized as a substrate. May facilitate the utilization of circulating citrate for the generation of metabolic energy and for the synthesis of fatty acid, and cholesterol.
Synonyms:Solute carrier family 13 member 5 (Na(+)/citrate cotransporter) (NaCT) (Sodium-coupled citrate transporter) (Sodium-dependent citrate transporter), SLC13A5, NACT
UniProt Protein Function:SLC13A5: High-affinity sodium/citrate cotransporter that mediates citrate entry into cells. The transport process is electrogenic; it is the trivalent form of citrate rather than the divalent form that is recognized as a substrate. May facilitate the utilization of circulating citrate for the generation of metabolic energy and for the synthesis of fatty acids and cholesterol. Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Transporter; Membrane protein, multi-pass; Transporter, SLC familyChromosomal Location of Human Ortholog: 17p13.1Cellular Component: basolateral plasma membrane; integral to membrane; plasma membraneMolecular Function: citrate transmembrane transporter activity; succinate transmembrane transporter activity; sodium:dicarboxylate symporter activityBiological Process: citrate transport; sodium ion transport; transmembrane transportDisease: Epileptic Encephalopathy, Early Infantile, 25
UniProt Protein Details:
NCBI Summary:This gene encodes a protein belonging to the solute carrier family 13 group of proteins. This family member is a sodium-dependent citrate cotransporter that may regulate metabolic processes. Mutations in this gene cause early infantile epileptic encephalopathy 25. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
UniProt Code:Q86YT5
NCBI GenInfo Identifier:219802232
NCBI Gene ID:284111
NCBI Accession:NP_001137310.1
UniProt Secondary Accession:Q86YT5,Q6ZMG1, B3KXR0, B7Z4P2, B7ZLB4, F8W7N2
UniProt Related Accession:Q86YT5
Molecular Weight:58,092 Da
NCBI Full Name:solute carrier family 13 member 5 isoform b
NCBI Synonym Full Names:solute carrier family 13 (sodium-dependent citrate transporter), member 5
NCBI Official Symbol:SLC13A5  
NCBI Official Synonym Symbols:NACT; mIndy; EIEE25  
NCBI Protein Information:solute carrier family 13 member 5; Na(+)/citrate cotransporter; Na+-coupled citrate transporter protein; sodium-dependent dicarboxylate transporter
UniProt Protein Name:Solute carrier family 13 member 5
UniProt Synonym Protein Names:Na(+)/citrate cotransporter; NaCT; Sodium-coupled citrate transporter; Sodium-dependent citrate transporter
Protein Family:
UniProt Gene Name:SLC13A5  
UniProt Entry Name:S13A5_HUMAN
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
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