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Anti-SLC12A6 Antibody (CAB8180)

SKU:
CAB8180
Product Type:
Antibody
Applications:
IF
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Signal Transduction
€139 - €419
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Description

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Antibody Name:SLC12A6 Rabbit Polyclonal Antibody
Antibody SKU:CAB8180
Antibody Size:20uL, 50uL, 100uL
Application:IF
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 60-190 of human SLC12A6 (NP_598408.1).
Application:IF
Recommended Dilution:IF 1:50 - 1:200
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 60-190 of human SLC12A6 (NP_598408.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MSEM SGAT TSLA TVAL DPPS DRTS HPQD VIED LSQN SITG EHSQ LLDD GHKK ARNA YLNN SNYE EGDE YFDK NLAL FEEE MDTR PKVS SLLN RMAN YTNL TQGA KEHE EAEN ITEG KKKP TKTP QMGT FMG
Gene ID:9990
Uniprot:Q9UHW9
Cellular Location:Basolateral cell membrane, Multi-pass membrane protein
Calculated MW:120kDa/121kDa/122kDa/125kDa/126kDa/127kDa
Observed MW:
Synonyms:SLC12A6, ACCPN, KCC3, KCC3A, KCC3B
Background:This gene is a member of the K-Cl cotransporter (KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The proteins encoded by this gene are activated by cell swelling induced by hypotonic conditions. Alternate splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are associated with agenesis of the corpus callosum with peripheral neuropathy.
UniProt Protein Function:KCC3: Mediates electroneutral potassium-chloride cotransport. May be activated by cell swelling. May contribute to cell volume homeostasis in single cells. Homomultimer and heteromultimer with other K-Cl cotransporters. Up-regulated by VEGF. Down-regulated by TNF. Highly expressed in heart, brain and kidney. Detected at lower levels in skeletal muscle, placenta, lung and pancreas. Detected in umbilical vein endothelial cells. Isoform 2 is more abundant in kidney. Isoform 5 is testis specific. Expressed in the proximal tubule of the kidney. Activated by N-ethylmaleimide (NEM). Inhibited by DIOA, bumetanide and furosemide. Inhibited by WNK3. Belongs to the SLC12A transporter family. 6 isoforms of the human protein are produced by alternative promoter.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Transporter, SLC family; Transporter; Membrane protein, integral

Chromosomal Location of Human Ortholog: 15q13

Cellular Component: basolateral plasma membrane; integral to plasma membrane; integral to membrane; plasma membrane

Molecular Function:potassium ion transmembrane transporter activity; protein kinase binding; potassium:chloride symporter activity

Biological Process: potassium ion import; ion transport; angiogenesis; transmembrane transport; potassium ion transport

Disease: Agenesis Of The Corpus Callosum With Peripheral Neuropathy

NCBI Summary:This gene is a member of the K-Cl cotransporter (KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The proteins encoded by this gene are activated by cell swelling induced by hypotonic conditions. Alternate splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are associated with agenesis of the corpus callosum with peripheral neuropathy. [provided by RefSeq, Jul 2008]
UniProt Code:Q9UHW9
NCBI GenInfo Identifier:110224449
NCBI Gene ID:9990
NCBI Accession:NP_598408.1
UniProt Secondary Accession:Q9UHW9,Q2VI00, Q7Z2E7, Q7Z4G5, Q8TDD4, Q9UFR2, Q9Y642 Q9Y665, A0AV76,
UniProt Related Accession:Q9UHW9
Molecular Weight:120,467 Da
NCBI Full Name:solute carrier family 12 member 6 isoform a
NCBI Synonym Full Names:solute carrier family 12 member 6
NCBI Official Symbol:SLC12A6  
NCBI Official Synonym Symbols:KCC3; ACCPN; KCC3A; KCC3B  
NCBI Protein Information:solute carrier family 12 member 6
UniProt Protein Name:Solute carrier family 12 member 6
UniProt Synonym Protein Names:Electroneutral potassium-chloride cotransporter 3; K-Cl cotransporter 3
Protein Family:Solute carrier family
UniProt Gene Name:SLC12A6  
UniProt Entry Name:S12A6_HUMAN
Anti-SLC12A6 Polyclonal Antibody (CAB8180)Immunofluorescence analysis of U2OS cells using SLC12A6 antibody (CAB8180) at dilution of 1:100. Blue: DAPI for nuclear staining.

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