The SLC12A6 Polyclonal Antibody (CAB8180) is a valuable tool for researchers studying SLC12A6, a member of the solute carrier family involved in ion transport and homeostasis. This polyclonal antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications.SLC12A6, also known as KCC3, plays a crucial role in regulating ion transport in cells, particularly in the nervous system. Dysregulation of SLC12A6 has been implicated in various neurological disorders, making it a key target for research in neuroscience and neurology.
This antibody binds specifically to the SLC12A6 protein, enabling researchers to detect and analyze its expression in different cell types.Understanding the function and regulation of SLC12A6 is essential for unraveling its role in health and disease, particularly in neurological conditions such as epilepsy, neuropathic pain, and neurodegenerative diseases. The SLC12A6 Polyclonal Antibody is an invaluable tool for investigating the biological mechanisms involving SLC12A6 and advancing our knowledge in this field.
Product Name:
SLC12A6 Rabbit Polyclonal Antibody
SKU:
CAB8180
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 60-190 of human SLC12A6 (NP_598408.1).
This gene is a member of the K-Cl cotransporter (KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The proteins encoded by this gene are activated by cell swelling induced by hypotonic conditions. Alternate splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are associated with agenesis of the corpus callosum with peripheral neuropathy.
Purification Method:
Affinity purification
Gene ID:
9990
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunofluorescence analysis of U2OS cells using SLC12A6 antibody (CAB8180) at dilution of 1:100. Blue: DAPI for nuclear staining.
