The SLC12A5 Polyclonal Antibody (CAB15487) is a valuable tool for researchers studying SLC12A5, a cell membrane transporter protein involved in ion transport and cellular homeostasis. This antibody, produced in rabbits, exhibits high reactivity with human samples, making it suitable for a variety of research applications.SLC12A5, also known as KCC2, plays a crucial role in ion transport across cell membranes, particularly in neuronal cells where it is involved in maintaining the inhibitory function of GABA receptors. Dysregulation of SLC12A5 has been linked to neurological disorders such as epilepsy and neuropathic pain, making it an important target for research in neurobiology and pharmacology.
The SLC12A5 Polyclonal Antibody binds specifically to the SLC12A5 protein, allowing for precise detection and analysis in various cell types and tissues. Its validated use in techniques such as Western blotting and immunofluorescence makes it a versatile tool for investigating the role of SLC12A5 in health and disease.By understanding the function and regulation of SLC12A5, researchers can gain insights into neurological disorders and potentially develop new therapeutic strategies targeting ion transport mechanisms. The SLC12A5 Polyclonal Antibody is a valuable resource for advancing our knowledge of this important protein and its implications for human health.
Product Name:
SLC12A5 Rabbit Polyclonal Antibody
SKU:
CAB15487
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 945-1025 of human SLC12A5 (NP_001128243.1).
K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The protein encoded by this gene is an integral membrane K-Cl cotransporter that can function in either a net efflux or influx pathway, depending on the chemical concentration gradients of potassium and chloride. The encoded protein can act as a homomultimer, or as a heteromultimer with other K-Cl cotransporters, to maintain chloride homeostasis in neurons. Alternative splicing results in two transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
57468
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from mouse brain, using SLC12A5 Rabbit pAb (CAB15487) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
