The SLC12A5 Polyclonal Antibody (CAB15486) is a valuable tool for researchers studying SLC12A5, a member of the solute carrier family of membrane transport proteins. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is specifically validated for use in Western blot applications. By targeting the SLC12A5 protein, this antibody enables detection and analysis in a variety of cell types, making it an ideal choice for studies in molecular biology and neuroscience.
SLC12A5 plays a crucial role in ion transport and homeostasis, particularly in the brain where it is involved in neuronal function and neurotransmission. Dysregulation of SLC12A5 has been linked to various neurological disorders, making it a key target for research into conditions such as epilepsy, schizophrenia, and bipolar disorder. Understanding the function and regulation of SLC12A5 is essential for developing targeted therapies that address these conditions at the molecular level.
Product Name:
SLC12A5 Rabbit Polyclonal Antibody
SKU:
CAB15486
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 945-1025 of human SLC12A5 (NP_001128243.1).
K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The protein encoded by this gene is an integral membrane K-Cl cotransporter that can function in either a net efflux or influx pathway, depending on the chemical concentration gradients of potassium and chloride. The encoded protein can act as a homomultimer, or as a heteromultimer with other K-Cl cotransporters, to maintain chloride homeostasis in neurons. Alternative splicing results in two transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
57468
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SLC12A5 Rabbit pAb (CAB15486) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
