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SLC12A4 Antibody (PACO42534)

SKU:
PACO42534
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • SLC12A4 Antibody PACO42534
  • SLC12A4 Antibody PACO42534
€339

Description

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SLC12A4 Antibody (PACO42534)

The SLC12A4 Polyclonal Antibody (PAC042534) is a valuable tool for researchers studying SLC12A4, a member of the SLC12A family of transporters involved in ion transport. This antibody, generated in rabbits, exhibits high specificity for human samples and has been validated for use in Western blot applications. It specifically targets the SLC12A4 protein, allowing for accurate detection and analysis in a variety of cell types.SLC12A4 is known for its role in ion transportation and regulation of cell volume, making it a key player in maintaining cellular homeostasis.

Dysfunction of SLC12A4 has been linked to various diseases, including hypertension and kidney disorders, making it a promising target for therapeutic interventions. Research on SLC12A4 may provide valuable insights into the mechanisms underlying these conditions and aid in the development of novel treatment strategies.

Antibody Name:SLC12A4 Antibody (PACO42534)
Antibody SKU:PACO42534
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, IHC
Recommended Dilutions:ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:Human
Immunogen:Recombinant Human Solute carrier family 12 member 4 protein (601-900AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageImmunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO42534 at dilution of 1:100.
Product ImageImmunohistochemistry of paraffin-embedded human placenta tissue using PACO42534 at dilution of 1:100.
Background:Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia. Isoform 4 has no transport activity.
Synonyms:Solute carrier family 12 member 4 (Electroneutral potassium-chloride cotransporter 1) (Erythroid K-Cl cotransporter 1) (hKCC1), SLC12A4, KCC1
UniProt Protein Function:KCC1: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia. Isoform 4 has no transport activity. Belongs to the SLC12A transporter family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Transporter; Membrane protein, integral; Membrane protein, multi-pass; Transporter, SLC familyChromosomal Location of Human Ortholog: 16q22.1Cellular Component: membrane; integral to plasma membrane; lysosomal membrane; plasma membraneMolecular Function: protein kinase binding; potassium:chloride symporter activityBiological Process: transport; ion transport; chloride transport; cell volume homeostasis; transmembrane transport; potassium ion transport
UniProt Protein Details:
NCBI Summary:This gene encodes a member of the SLC12A transporter family. The encoded protein mediates the coupled movement of potassium and chloride ions across the plasma membrane. This gene is expressed ubiquitously. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2013]
UniProt Code:Q9UP95
NCBI GenInfo Identifier:27151691
NCBI Gene ID:6560
NCBI Accession:Q9UP95.2
UniProt Secondary Accession:Q9UP95,O60632, O75893, Q13953, Q96LD5, B4DF69, B4DR04 B4DZ82, B7ZAV0, F5H066
UniProt Related Accession:Q9UP95
Molecular Weight:1085
NCBI Full Name:Solute carrier family 12 member 4
NCBI Synonym Full Names:solute carrier family 12 (potassium/chloride transporter), member 4
NCBI Official Symbol:SLC12A4  
NCBI Official Synonym Symbols:KCC1  
NCBI Protein Information:solute carrier family 12 member 4; hKCC1; CTC-479C5.17; erythroid K-Cl cotransporter 1; potassium/chloride cotransporter 1; electroneutral potassium-chloride cotransporter 1; solute carrier family 12 (potassium/chloride transporters), member 4
UniProt Protein Name:Solute carrier family 12 member 4
UniProt Synonym Protein Names:Electroneutral potassium-chloride cotransporter 1; Erythroid K-Cl cotransporter 1; hKCC1
Protein Family:Solute carrier family
UniProt Gene Name:SLC12A4  
UniProt Entry Name:S12A4_HUMAN
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