SLC12A4 Antibody (PACO14997)
- SKU:
- PACO14997
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
SLC12A4 Antibody (PACO14997)
The SLC12A4 Polyclonal Antibody (PACO14997) is a valuable tool for researchers studying the SLC12A4 protein, a member of the solute carrier family known for its role in ion transport and homeostasis. This antibody, produced in rabbits, is highly specific to human SLC12A4 and has been validated for use in Western blot applications.SLC12A4 plays a crucial role in the regulation of ion balance in cells, particularly in the kidney where it is involved in sodium and potassium transport. Dysregulation of SLC12A4 activity has been linked to various diseases such as hypertension and kidney disorders.
Therefore, studying the expression and function of SLC12A4 with this antibody can provide important insights into these conditions and potentially identify new therapeutic targets.With its high reactivity and specificity, the SLC12A4 Polyclonal Antibody (PACO14997) is a valuable tool for researchers looking to understand the role of SLC12A4 in health and disease, particularly in the context of ion transport and cell homeostasis.
| Antibody Name: | SLC12A4 Antibody (PACO14997) |
| Antibody SKU: | PACO14997 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Fusion protein of human SLC12A4 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO14997(SLC12A4 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO14997(SLC12A4 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | This gene encodes a member of the SLC12A transporter family. The encoded protein mediates the coupled movement of potassium and chloride ions across the plasma membrane. This gene is expressed ubiquitously. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl- exit in NaCl absorbing epithelia. |
| Synonyms: | solute carrier family 12 (potassium/chloride transporters), member 4 |
| UniProt Protein Function: | KCC1: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia. Isoform 4 has no transport activity. Belongs to the SLC12A transporter family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Transporter; Membrane protein, integral; Membrane protein, multi-pass; Transporter, SLC familyChromosomal Location of Human Ortholog: 16q22.1Cellular Component: membrane; integral to plasma membrane; lysosomal membrane; plasma membraneMolecular Function: protein kinase binding; potassium:chloride symporter activityBiological Process: transport; ion transport; chloride transport; cell volume homeostasis; transmembrane transport; potassium ion transport |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the SLC12A transporter family. The encoded protein mediates the coupled movement of potassium and chloride ions across the plasma membrane. This gene is expressed ubiquitously. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2013] |
| UniProt Code: | Q9UP95 |
| NCBI GenInfo Identifier: | 27151691 |
| NCBI Gene ID: | 6560 |
| NCBI Accession: | Q9UP95.2 |
| UniProt Secondary Accession: | Q9UP95,O60632, O75893, Q13953, Q96LD5, B4DF69, B4DR04 B4DZ82, B7ZAV0, F5H066 |
| UniProt Related Accession: | Q9UP95 |
| Molecular Weight: | 1085 |
| NCBI Full Name: | Solute carrier family 12 member 4 |
| NCBI Synonym Full Names: | solute carrier family 12 (potassium/chloride transporter), member 4 |
| NCBI Official Symbol: | SLC12A4Â Â |
| NCBI Official Synonym Symbols: | KCC1Â Â |
| NCBI Protein Information: | solute carrier family 12 member 4; hKCC1; CTC-479C5.17; erythroid K-Cl cotransporter 1; potassium/chloride cotransporter 1; electroneutral potassium-chloride cotransporter 1; solute carrier family 12 (potassium/chloride transporters), member 4 |
| UniProt Protein Name: | Solute carrier family 12 member 4 |
| UniProt Synonym Protein Names: | Electroneutral potassium-chloride cotransporter 1; Erythroid K-Cl cotransporter 1; hKCC1 |
| Protein Family: | Solute carrier family |
| UniProt Gene Name: | SLC12A4Â Â |
| UniProt Entry Name: | S12A4_HUMAN |
| Antibodies |
| SLC12A4 Antibody (PACO12239) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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