SLC12A4 Antibody (PACO14996)
- SKU:
- PACO14996
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
SLC12A4 Antibody (PACO14996)
The SLC12A4 Polyclonal Antibody (PACO14996) is a valuable tool for researchers studying SLC12A4, a member of the SLC12A transporter family involved in ion transport and homeostasis. This antibody is raised in rabbits and is specifically reactive with human samples, making it ideal for use in a variety of research applications.SLC12A4 plays a crucial role in ion regulation and transport in a variety of cell types, making it a key target for studies in physiology, neuroscience, and kidney function. This antibody binds specifically to SLC12A4 protein, allowing for accurate detection and analysis in Western blot applications.
Understanding the function and regulation of SLC12A4 is important for research in areas such as kidney physiology, neural signaling, and electrolyte balance.By utilizing the SLC12A4 Polyclonal Antibody (PACO14996), researchers can gain valuable insights into the role of SLC12A4 in various biological processes and diseases. This antibody provides a reliable tool for studying SLC12A4 function and its potential as a therapeutic target in conditions related to ion transport and homeostasis.
| Antibody Name: | SLC12A4 Antibody (PACO14996) |
| Antibody SKU: | PACO14996 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Fusion protein of human SLC12A4 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO14996(SLC12A4 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO14996(SLC12A4 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | This gene encodes a member of the SLC12A transporter family. The encoded protein mediates the coupled movement of potassium and chloride ions across the plasma membrane. This gene is expressed ubiquitously. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl- exit in NaCl absorbing epithelia. |
| Synonyms: | solute carrier family 12 (potassium/chloride transporters), member 4 |
| UniProt Protein Function: | KCC1: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia. Isoform 4 has no transport activity. Belongs to the SLC12A transporter family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Transporter; Membrane protein, integral; Membrane protein, multi-pass; Transporter, SLC familyChromosomal Location of Human Ortholog: 16q22.1Cellular Component: membrane; integral to plasma membrane; lysosomal membrane; plasma membraneMolecular Function: protein kinase binding; potassium:chloride symporter activityBiological Process: transport; ion transport; chloride transport; cell volume homeostasis; transmembrane transport; potassium ion transport |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the SLC12A transporter family. The encoded protein mediates the coupled movement of potassium and chloride ions across the plasma membrane. This gene is expressed ubiquitously. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2013] |
| UniProt Code: | Q9UP95 |
| NCBI GenInfo Identifier: | 27151691 |
| NCBI Gene ID: | 6560 |
| NCBI Accession: | Q9UP95.2 |
| UniProt Secondary Accession: | Q9UP95,O60632, O75893, Q13953, Q96LD5, B4DF69, B4DR04 B4DZ82, B7ZAV0, F5H066 |
| UniProt Related Accession: | Q9UP95 |
| Molecular Weight: | 1085 |
| NCBI Full Name: | Solute carrier family 12 member 4 |
| NCBI Synonym Full Names: | solute carrier family 12 (potassium/chloride transporter), member 4 |
| NCBI Official Symbol: | SLC12A4Â Â |
| NCBI Official Synonym Symbols: | KCC1Â Â |
| NCBI Protein Information: | solute carrier family 12 member 4; hKCC1; CTC-479C5.17; erythroid K-Cl cotransporter 1; potassium/chloride cotransporter 1; electroneutral potassium-chloride cotransporter 1; solute carrier family 12 (potassium/chloride transporters), member 4 |
| UniProt Protein Name: | Solute carrier family 12 member 4 |
| UniProt Synonym Protein Names: | Electroneutral potassium-chloride cotransporter 1; Erythroid K-Cl cotransporter 1; hKCC1 |
| Protein Family: | Solute carrier family |
| UniProt Gene Name: | SLC12A4Â Â |
| UniProt Entry Name: | S12A4_HUMAN |
| Antibodies |
| SLC12A4 Antibody (PACO12239) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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