Anti-SLC12A4 Antibody (PACO14996)

Antibody Name:	SLC12A4 Antibody (PACO14996)
Antibody SKU:	PACO14996
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:	Human, Mouse, Rat
Immunogen:	Fusion protein of human SLC12A4

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO14996(SLC12A4 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
	The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO14996(SLC12A4 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).

Background:

This gene encodes a member of the SLC12A transporter family. The encoded protein mediates the coupled movement of potassium and chloride ions across the plasma membrane. This gene is expressed ubiquitously. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl- exit in NaCl absorbing epithelia.

Synonyms:

solute carrier family 12 (potassium/chloride transporters), member 4

UniProt Protein Function:	KCC1: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia. Isoform 4 has no transport activity. Belongs to the SLC12A transporter family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Transporter; Membrane protein, integral; Membrane protein, multi-pass; Transporter, SLC familyChromosomal Location of Human Ortholog: 16q22.1Cellular Component: membrane; integral to plasma membrane; lysosomal membrane; plasma membraneMolecular Function: protein kinase binding; potassium:chloride symporter activityBiological Process: transport; ion transport; chloride transport; cell volume homeostasis; transmembrane transport; potassium ion transport
UniProt Protein Details:
NCBI Summary:	This gene encodes a member of the SLC12A transporter family. The encoded protein mediates the coupled movement of potassium and chloride ions across the plasma membrane. This gene is expressed ubiquitously. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2013]
UniProt Code:	Q9UP95
NCBI GenInfo Identifier:	27151691
NCBI Gene ID:	6560
NCBI Accession:	Q9UP95.2
UniProt Secondary Accession:	Q9UP95,O60632, O75893, Q13953, Q96LD5, B4DF69, B4DR04 B4DZ82, B7ZAV0, F5H066
UniProt Related Accession:	Q9UP95
Molecular Weight:	1085
NCBI Full Name:	Solute carrier family 12 member 4
NCBI Synonym Full Names:	solute carrier family 12 (potassium/chloride transporter), member 4
NCBI Official Symbol:	SLC12A4
NCBI Official Synonym Symbols:	KCC1
NCBI Protein Information:	solute carrier family 12 member 4; hKCC1; CTC-479C5.17; erythroid K-Cl cotransporter 1; potassium/chloride cotransporter 1; electroneutral potassium-chloride cotransporter 1; solute carrier family 12 (potassium/chloride transporters), member 4
UniProt Protein Name:	Solute carrier family 12 member 4
UniProt Synonym Protein Names:	Electroneutral potassium-chloride cotransporter 1; Erythroid K-Cl cotransporter 1; hKCC1
Protein Family:	Solute carrier family
UniProt Gene Name:	SLC12A4
UniProt Entry Name:	S12A4_HUMAN

Antibodies

SLC12A4 Antibody (PACO12239)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)