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SLC12A4 Antibody (PACO14996)

SKU:
PACO14996
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • SLC12A4 Antibody PACO14996
  • SLC12A4 Antibody PACO14996
€339

Description

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SLC12A4 Antibody (PACO14996)

The SLC12A4 Polyclonal Antibody (PACO14996) is a valuable tool for researchers studying SLC12A4, a member of the SLC12A transporter family involved in ion transport and homeostasis. This antibody is raised in rabbits and is specifically reactive with human samples, making it ideal for use in a variety of research applications.SLC12A4 plays a crucial role in ion regulation and transport in a variety of cell types, making it a key target for studies in physiology, neuroscience, and kidney function. This antibody binds specifically to SLC12A4 protein, allowing for accurate detection and analysis in Western blot applications.

Understanding the function and regulation of SLC12A4 is important for research in areas such as kidney physiology, neural signaling, and electrolyte balance.By utilizing the SLC12A4 Polyclonal Antibody (PACO14996), researchers can gain valuable insights into the role of SLC12A4 in various biological processes and diseases. This antibody provides a reliable tool for studying SLC12A4 function and its potential as a therapeutic target in conditions related to ion transport and homeostasis.

Antibody Name:SLC12A4 Antibody (PACO14996)
Antibody SKU:PACO14996
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, IHC
Recommended Dilutions:ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:Human, Mouse, Rat
Immunogen:Fusion protein of human SLC12A4
Form:Liquid
Storage Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:Antigen affinity purification
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageThe image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO14996(SLC12A4 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
Product ImageThe image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO14996(SLC12A4 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
Background:This gene encodes a member of the SLC12A transporter family. The encoded protein mediates the coupled movement of potassium and chloride ions across the plasma membrane. This gene is expressed ubiquitously. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl- exit in NaCl absorbing epithelia.
Synonyms:solute carrier family 12 (potassium/chloride transporters), member 4
UniProt Protein Function:KCC1: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia. Isoform 4 has no transport activity. Belongs to the SLC12A transporter family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Transporter; Membrane protein, integral; Membrane protein, multi-pass; Transporter, SLC familyChromosomal Location of Human Ortholog: 16q22.1Cellular Component: membrane; integral to plasma membrane; lysosomal membrane; plasma membraneMolecular Function: protein kinase binding; potassium:chloride symporter activityBiological Process: transport; ion transport; chloride transport; cell volume homeostasis; transmembrane transport; potassium ion transport
UniProt Protein Details:
NCBI Summary:This gene encodes a member of the SLC12A transporter family. The encoded protein mediates the coupled movement of potassium and chloride ions across the plasma membrane. This gene is expressed ubiquitously. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2013]
UniProt Code:Q9UP95
NCBI GenInfo Identifier:27151691
NCBI Gene ID:6560
NCBI Accession:Q9UP95.2
UniProt Secondary Accession:Q9UP95,O60632, O75893, Q13953, Q96LD5, B4DF69, B4DR04 B4DZ82, B7ZAV0, F5H066
UniProt Related Accession:Q9UP95
Molecular Weight:1085
NCBI Full Name:Solute carrier family 12 member 4
NCBI Synonym Full Names:solute carrier family 12 (potassium/chloride transporter), member 4
NCBI Official Symbol:SLC12A4  
NCBI Official Synonym Symbols:KCC1  
NCBI Protein Information:solute carrier family 12 member 4; hKCC1; CTC-479C5.17; erythroid K-Cl cotransporter 1; potassium/chloride cotransporter 1; electroneutral potassium-chloride cotransporter 1; solute carrier family 12 (potassium/chloride transporters), member 4
UniProt Protein Name:Solute carrier family 12 member 4
UniProt Synonym Protein Names:Electroneutral potassium-chloride cotransporter 1; Erythroid K-Cl cotransporter 1; hKCC1
Protein Family:Solute carrier family
UniProt Gene Name:SLC12A4  
UniProt Entry Name:S12A4_HUMAN
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