The SLC12A4 Polyclonal Antibody (PAC012239) is a valuable tool for researchers studying SLC12A4, a protein involved in ion transport and kidney function. This antibody, generated in rabbits, exhibits high specificity and sensitivity for human samples, making it suitable for various applications such as Western blotting.SLC12A4, also known as sodium-potassium-chloride cotransporter 1, plays a vital role in maintaining electrolyte balance and cell volume regulation in the kidney. Dysregulation of SLC12A4 has been linked to various kidney disorders, making it an intriguing target for research in nephrology and renal physiology.
By using the SLC12A4 Polyclonal Antibody, researchers can explore the expression and function of SLC12A4 in different cell types and tissues, providing valuable insights into its physiological and pathological roles. With its versatility and reliability, this antibody is a valuable asset for studies aimed at understanding the complex mechanisms of ion transport and kidney function.
solute carrier family 12 (potassium/chloride transporters), member 4;SLC12A4;FLJ17069;FLJ40489;KCC1 ;
UniProt Protein Function:
KCC1: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia. Isoform 4 has no transport activity. Belongs to the SLC12A transporter family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Transporter; Membrane protein, integral; Membrane protein, multi-pass; Transporter, SLC familyChromosomal Location of Human Ortholog: 16q22.1Cellular Component: membrane; integral to plasma membrane; lysosomal membrane; plasma membraneMolecular Function: protein kinase binding; potassium:chloride symporter activityBiological Process: transport; ion transport; chloride transport; cell volume homeostasis; transmembrane transport; potassium ion transport
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the SLC12A transporter family. The encoded protein mediates the coupled movement of potassium and chloride ions across the plasma membrane. This gene is expressed ubiquitously. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2013]
