SLC12A3 Rabbit Polyclonal Antibody (CAB18382)
- SKU:
- CAB18382
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | SLC12A3 Rabbit Polyclonal Antibody |
SKU: | CAB18382 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Monkey |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human SLC12A3 (NP_000330.2). |
Sequence: | MAEL PTTE TPGD ATLC SGRF TIST LLSS DEPS PPAA YDSS HPSH LTHS STFC MRTF GYNT IDVV PTYE HYAN STQP GEPR KVRP TLAD LHSF LKQE GRHL HALA FDSR PSHE MTDG LVEG EAGT SSEK NPEE PVRF GWVK |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:1000 - 1:5000 |
Synonyms: | NCC; TSC; NCCT; SLC12A3 |
Positive Sample: | 293T,COS-7,Mouse kidney |
Cellular Localization: | apical plasma membrane, cytosol, extracellular exosome, plasma membrane |
Calculated MW: | 113kDa |
Observed MW: | 100-170kDa |
This gene encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. Mutations in this gene cause Gitelman syndrome, a disease similar to Bartter's syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 6559 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |