SLC12A1 Rabbit Polyclonal Antibody (CAB12999)
- SKU:
- CAB12999
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
Product Name: | SLC12A1 Rabbit Polyclonal Antibody |
SKU: | CAB12999 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human SLC12A1 (NP_000329.2). |
Sequence: | FGDE AQKR LRIS FRPG NQEC YDNF LQSG ETAK TDAS FHAY DSHT NTYY LQTF GHNT MDAV PKIE YYRN TGSI SGPK VNRP SLLE IHEQ LAKN VAVT PSSA D |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | BSC; BSC1; CCC2; BSC-1; NKCC2; SLC12A1 |
Positive Sample: | Mouse kidney,Rat kidney |
Conjugate: | Unconjugated |
Cellular Localization: | Membrane, Multi-pass membrane protein. |
Calculated MW: | 121kDa |
Observed MW: | 150kDa |
This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.
Purification Method: | Affinity purification |
Gene ID: | 6557 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |