The SLC11A2 Polyclonal Antibody (CAB10231) is a valuable tool for researchers studying the SLC11A2 protein, also known as DMT1. This protein is involved in the transport of divalent metals such as iron and manganese across cell membranes, making it essential for maintaining metal homeostasis in various tissues.Raised in rabbits, this antibody is highly specific to human samples and has been validated for use in Western blot applications. By binding to the SLC11A2 protein, researchers can effectively detect and analyze its expression in different cell types, facilitating studies in fields such as metabolism, neurobiology, and iron-related disorders.
The role of SLC11A2 in metal ion transport and its implications for various physiological processes make it a promising target for investigating disorders like anemia, neurodegenerative diseases, and iron overload conditions. By understanding the function of SLC11A2, researchers can develop targeted therapies that regulate metal ion transport and potentially alleviate symptoms associated with these disorders.
Product Name:
DMT1 Rabbit Polyclonal Antibody
SKU:
CAB10231
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-63 of human DMT1/SLC11A2 (NP_001167597.1).
This gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
4891
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using DMT1/SLC11A2 Rabbit pAb (CAB10231) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
