The SLC10A6 Antibody (PAC035970) is a vital tool for researchers studying the SLC10A6 protein, which is involved in the uptake and transport of bile acids in the liver and intestine. This polyclonal antibody, produced through immunization of rabbits, shows high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the SLC10A6 protein, this antibody enables accurate detection and analysis in various cell types, making it an excellent choice for studies in liver biology, metabolism, and related diseases.
SLC10A6, also known as the sodium/bile acid cotransporter, plays a crucial role in maintaining bile acid homeostasis and lipid metabolism. Dysregulation of SLC10A6 function has been linked to liver diseases, including cholestasis and non-alcoholic fatty liver disease, making it an intriguing target for research in hepatology and gastroenterology. Understanding the mechanisms of SLC10A6 function is essential for developing potential therapies targeting bile acid transport and metabolism in liver disorders.
Antibody Name:
SLC10A6 Antibody (PACO35970)
Antibody SKU:
PACO35970
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Human
Immunogen:
Recombinant Human Solute carrier family 10 member 6 protein (312-377AA)
Transports sulfoconjugated steroid hormones, as well as taurolithocholic acid, 3-sulfate and sulfoconjugated pyrenes in a sodium-dependent manner.
Synonyms:
Solute carrier family 10 member 6 (Sodium-dependent organic anion transporter), SLC10A6, SOAT
UniProt Protein Function:
SLC10A6: Transports sulfoconjugated steroid hormones, as well as taurolithocholic acid-3-sulfate and sulfoconjugated pyrenes in a sodium-dependent manner. Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.Protein type: Membrane protein, multi-pass; Transporter; Transporter, SLC family; Membrane protein, integralChromosomal Location of Human Ortholog: 4q21.3Cellular Component: integral to plasma membrane; plasma membraneMolecular Function: bile acid:sodium symporter activity; sodium-dependent organic anion transmembrane transporter activityBiological Process: bile acid and bile salt transport; sodium ion transport; sodium-dependent organic anion transport; transmembrane transport
