The SLC10A3 Polyclonal Antibody (PACO12236) is a valuable tool for researchers studying SLC10A3, a member of the solute carrier family involved in the transport of bile acids and other substrates. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By targeting the SLC10A3 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an ideal choice for investigations in the fields of molecular biology and metabolism research.SLC10A3, also known as the sodium bile acid cotransporter family member 3, plays a crucial role in the uptake of bile acids in the liver and intestines, impacting various physiological processes such as bile acid homeostasis and cholesterol metabolism.
Dysregulation of SLC10A3 has been linked to disorders like cholestasis and lipid metabolism abnormalities, making it a promising target for studies on liver diseases and metabolic disorders. Understanding the function of SLC10A3 is essential for the development of therapeutic interventions aimed at treating these conditions.
solute carrier family 10 (sodium/bile acid, cotransporter family), member 3;SLC10A3;DXS253E;P3 ;
UniProt Protein Function:
SLC10A3: The ubiquitous expression and the conservation of the sequence in distant animal species suggest that the gene codes for a protein with housekeeping functions. Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: Xq28Cellular Component: integral to plasma membraneMolecular Function: bile acid:sodium symporter activityBiological Process: bile acid and bile salt transport; response to retinoic acid; transmembrane transport
UniProt Protein Details:
NCBI Summary:
This gene maps to a GC-rich region of the X chromosome and was identified by its proximity to a CpG island. It is thought to be a housekeeping gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2008]
