The SLC10A1 Polyclonal Antibody (CAB12721) is a valuable tool for researchers studying SLC10A1, a key protein involved in the transport of bile acids across cell membranes. This antibody is produced in rabbits and has been rigorously validated for use in Western blot applications, making it suitable for a wide range of research projects.SLC10A1, also known as the sodium/bile acid cotransporter, plays a crucial role in the absorption of bile acids in the small intestine and liver. Dysregulation of SLC10A1 has been implicated in various liver diseases and disorders related to bile acid metabolism. By targeting SLC10A1 with this specific antibody, researchers can accurately detect and analyze the protein in different cell types, allowing for a deeper understanding of its function and potential implications in disease pathology.
By utilizing the SLC10A1 Polyclonal Antibody (CAB12721), researchers can further explore the intricate mechanisms involved in bile acid transport and its impact on liver health. This antibody offers a reliable and efficient means of investigating SLC10A1 expression and localization in various biological samples, paving the way for new insights and advancements in the field of hepatology and related research areas.
Product Name:
SLC10A1 Rabbit Polyclonal Antibody
SKU:
CAB12721
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human SLC10A1 (NP_003040.1).
The protein encoded by this gene belongs to the sodium/bile acid cotransporter family, which are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids; the ileal sodium/bile acid cotransporter with an apical cell localization that absorbs bile acids from the intestinal lumen, bile duct and kidney, and the liver-specific sodium/bile acid cotransporter, represented by this protein, that is found in the basolateral membranes of hepatocytes. Bile acids are the catabolic product of cholesterol metabolism, hence this protein is important for cholesterol homeostasis.
Purification Method:
Affinity purification
Gene ID:
6554
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from mouse brain, using SLC10A1 Rabbit pAb (CAB12721) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
