The SLAMF8 Monoclonal Antibody (PAC029916) is a valuable tool for researchers studying SLAMF8, a cell surface receptor known for its role in immune regulation and cell signaling pathways. This antibody, produced through hybridoma technology, specifically targets SLAMF8 and is highly specific for human samples.SLAMF8, also known as CD353, is a member of the signaling lymphocytic activation molecule (SLAM) family and is involved in modulating immune responses and regulating T cell activation and function. The SLAMF8 antibody is suitable for use in various applications, including flow cytometry, immunofluorescence, and immunohistochemistry, enabling researchers to analyze SLAMF8 expression in different cell types and tissues.
The expression and function of SLAMF8 have been implicated in various diseases, including cancer, autoimmune disorders, and infectious diseases. By studying the role of SLAMF8 in these conditions, researchers can gain valuable insights into disease mechanisms and potentially identify new therapeutic targets for intervention. The SLAMF8 Monoclonal Antibody is a crucial tool for advancing research in immunology, cancer biology, and other areas of biomedical science.
Antibody Name:
SLAMF8 Antibody (PACO29916)
Antibody SKU:
PACO29916
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human SLAM family member 8 protein (23-233AA)
Immunohistochemistry of paraffin-embedded human spleen tissue using PACO29916 at dilution of 1:100.
Background:
May play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor.
Synonyms:
SLAM family member 8 (B-lymphocyte activator macrophage expressed) (BCM-like membrane protein) (CD antigen CD353), SLAMF8, BLAME
UniProt Protein Function:
SLAMF8: May play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 1q23.2Cellular Component: integral to membraneMolecular Function: receptor activityBiological Process: regulation of NAD(P)H oxidase activity; regulation of kinase activity; defense response to bacterium
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the CD2 family of cell surface proteins involved in lymphocyte activation. These proteins are characterized by Ig domains. This protein is expressed in lymphoid tissues, and studies of a similar protein in mouse suggest that it may function during B cell lineage commitment. The gene is found in a region of chromosome 1 containing many CD2 genes. [provided by RefSeq, Jul 2008]
