The SLAMF6 Polyclonal Antibody (CAB10338) is a powerful tool for researchers studying the SLAMF6 protein, a key regulator of immune responses. This antibody, produced in rabbits, offers high reactivity with human samples and has been validated for use in Western blotting applications. By binding specifically to SLAMF6, researchers can accurately detect and analyze this important protein in a variety of cell types, making it ideal for investigations in immunology and cancer research.SLAMF6, also known as CD352, is a signaling lymphocytic activation molecule family member 6 that plays a crucial role in regulating immune cell activation and function.
Its involvement in immune signaling pathways makes it a promising target for studies investigating immune system dysregulation, autoimmune diseases, and cancer progression. By studying the function of SLAMF6, researchers can gain valuable insights into potential therapeutic strategies for managing these complex conditions.
Product Name:
SLAMF6 Rabbit Polyclonal Antibody
SKU:
CAB10338
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 24-215 of human SLAMF6 (NP_001171643.1).
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
37kDa
Observed MW:
60kDa
The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Purification Method:
Affinity purification
Gene ID:
114836
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using SLAMF6 antibody (CAB10338) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
