SKIL Rabbit Polyclonal Antibody (CAB5844)
- SKU:
- CAB5844
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | SKIL Rabbit Polyclonal Antibody |
SKU: | CAB5844 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 350-450 of human SKIL (NP_005405.2). |
Sequence: | EMKE KFSM RSGK RNQS KTDA PSGM ELQS WYPV IKQE GDHV SQTH SFLH PSYY LYMC DKVV APNV SLTS AVSQ SKEL TKTE ASKS ISRQ SEKA HSSG KLQK T |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | SNO; SnoA; SnoI; SnoN; SKIL |
Positive Sample: | Mouse testis,Rat kidney |
Conjugate: | Unconjugated |
Cellular Localization: | acrosomal vesicle, cytoplasm, nucleoplasm, nucleus, PML body |
Calculated MW: | 77kDa |
Observed MW: | 75kDa |
The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 6498 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |