The SKAP2 Polyclonal Antibody (CAB6435) is a valuable tool for researchers studying the SKAP2 protein, a key regulator of T cell activation and immune response. This antibody, raised in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the SKAP2 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an essential component for studies in immunology and cancer research.SKAP2 is known to be involved in T cell activation and signaling pathways, playing a crucial role in the regulation of immune responses.
Understanding the function of SKAP2 is important for unraveling the mechanisms of immune cell activation and for developing targeted therapies for diseases such as cancer, autoimmune disorders, and inflammatory conditions. The SKAP2 Polyclonal Antibody provides researchers with a powerful tool to further explore the role of SKAP2 in these pathological processes and to potentially identify new treatment strategies.
Product Name:
SKAP2 Rabbit Polyclonal Antibody
SKU:
CAB6435
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human SKAP2 (NP_003921.2).
The protein encoded by this gene shares homology with Src kinase-associated phosphoprotein 1, and is a substrate of Src family kinases. It is an adaptor protein that is thought to play an essential role in the Src signaling pathway, and in regulating proper activation of the immune system. This protein contains an amino terminal coiled-coil domain for self-dimerization, a plecskstrin homology (PH) domain required for interactions with lipids at the membrane, and a Src homology (SH3) domain at the carboxy terminus. Some reports indicate that this protein inhibits actin polymerization through interactions with actin assembly factors, and might negatively regulate the invasiveness of tumors by modulating actin assembly. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
8935
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of mouse lung, using SKAP2 antibody (CAB6435) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
