The SKAP2 Polyclonal Antibody (CAB15750) is a valuable tool for researchers studying the SKAP2 protein, which plays a key role in immune cell activation and signaling pathways. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the SKAP2 protein, researchers can delve into the mechanisms underlying immune cell activation and potentially uncover new therapeutic targets for immune-related disorders.SKAP2 is a signaling adaptor protein that is involved in T cell receptor signaling and immune synapse formation. Its binding to other proteins in the signaling cascade helps modulate immune responses and regulate T cell activation.
Understanding the function of SKAP2 is crucial for gaining insights into immune system function and developing new strategies for immunotherapy.With its high reactivity and specificity, the SKAP2 Polyclonal Antibody (CAB15750) is a valuable tool for researchers in immunology, cancer research, and autoimmune diseases. By enabling the detection and analysis of the SKAP2 protein in various cell types, this antibody opens up new possibilities for studying immune cell activation and developing targeted therapies for immune-related disorders.
Product Name:
SKAP2 Rabbit Polyclonal Antibody
SKU:
CAB15750
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human SKAP2 (NP_003921.2).
The protein encoded by this gene shares homology with Src kinase-associated phosphoprotein 1, and is a substrate of Src family kinases. It is an adaptor protein that is thought to play an essential role in the Src signaling pathway, and in regulating proper activation of the immune system. This protein contains an amino terminal coiled-coil domain for self-dimerization, a plecskstrin homology (PH) domain required for interactions with lipids at the membrane, and a Src homology (SH3) domain at the carboxy terminus. Some reports indicate that this protein inhibits actin polymerization through interactions with actin assembly factors, and might negatively regulate the invasiveness of tumors by modulating actin assembly. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
8935
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of Mouse lung, using SKAP2 Rabbit pAb (CAB15750) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
