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SIX5 Transcription Factor Activity Assay

SKU:
TFAB00202
Product Type:
ELISA Kit
ELISA Type:
Transcription Factor Assay
Analytes:
SIX5
Reactivity:
Human
Mouse
€599
Frequently bought together:

Description

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SIX5 Transcription Factor Activity Assay

The SIX5 Transcription Factor Activity Assay kit is specifically designed for the quantitative measurement of SIX5 transcription factor activity in various biological samples. This assay offers high sensitivity and precision, ensuring accurate and reliable results for your research needs.SIX5 is a critical transcription factor that plays a key role in regulating gene expression, cell differentiation, and development. Dysregulation of SIX5 has been linked to various diseases, including cancer, diabetes, and neurological disorders.

Therefore, the SIX5 Transcription Factor Activity Assay provides valuable insights into the molecular mechanisms underlying these conditions and may aid in the development of novel therapeutic strategies.With easy-to-follow protocols and a user-friendly format, the SIX5 Transcription Factor Activity Assay kit is suitable for both experienced researchers and beginners. Trust Assay Genie for high-quality and innovative tools for your research endeavors. Visit our website for more information and to order your kit today.

Product Name:SIX5 Transcription Factor Activity Assay
Product Code:TFAB00202
Target:SIX5
Reactivity:Human, Mouse
Sample Types:Nuclear or cell lysates

The Assay Genie SIX5 transcription factor activity assay allows for the detection and qualitative analysis of endogenous levels of activated transcription factors in a variety of nuclear and cell lysates

Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.

Assay Time:4.5 hours
Detection Method:Colorimetric 450 nm
Size:12 x 8-Well Microstrips
Storage:4°C for 6 months
UniProt Protein Function:SIX5: Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5'-GGTGTCAG-3' motif present in the ARE regulatory element of ATP1A1. Binds a 5'- TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter. Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3. Defects in SIX5 are the cause of branchiootorenal syndrome type 2 (BOR2). BOR is an autosomal dominant disorder manifested by various combinations of preauricular pits, branchial fistulae or cysts, lacrimal duct stenosis, hearing loss, structural defects of the outer, middle, or inner ear, and renal dysplasia. Associated defects include asthenic habitus, long narrow facies, constricted palate, deep overbite, and myopia. Hearing loss may be due to mondini type cochlear defect and stapes fixation. Penetrance of BOR syndrome is high, although expressivity can be extremely variable. Belongs to the SIX/Sine oculis homeobox family.
UniProt Protein Details:

Protein type:Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 19q13.32

Cellular Component: cytoplasm; Golgi apparatus; intracellular membrane-bound organelle; nucleoplasm

Molecular Function:protein binding

Disease: Branchiootorenal Syndrome 2

NCBI Summary:The protein encoded by this gene is a homeodomain-containing transcription factor that appears to function in the regulation of organogenesis. This gene is located downstream of the dystrophia myotonica-protein kinase gene. Mutations in this gene are a cause of branchiootorenal syndrome type 2. [provided by RefSeq, Jul 2009]
UniProt Code:Q8N196
NCBI GenInfo Identifier:150421671
NCBI Gene ID:147912
NCBI Accession:Q8N196.3
UniProt Related Accession:Q8N196
Molecular Weight:74,562 Da
NCBI Full Name:Homeobox protein SIX5
NCBI Synonym Full Names:SIX homeobox 5
NCBI Official Symbol:SIX5  
NCBI Official Synonym Symbols:BOR2; DMAHP  
NCBI Protein Information:homeobox protein SIX5
UniProt Protein Name:Homeobox protein SIX5
UniProt Synonym Protein Names:DM locus-associated homeodomain protein; Sine oculis homeobox homolog 5
Protein Family:Homeobox protein
UniProt Gene Name:SIX5  
UniProt Entry Name:SIX5_HUMAN
Antibodies
Anti-SIX5 Antibody (CAB15960)
SIX5 Antibody (PACO02508)
SIX5 Antibody (PACO22380)

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