The SIRT6 Rabbit Monoclonal Antibody (CAB3591) is an essential tool for researchers studying SIRT6, a key regulator of aging and metabolism. This antibody, produced in rabbits, shows high specificity and sensitivity for human samples, making it ideal for use in Western blot applications. By binding to the SIRT6 protein, this antibody enables researchers to detect and analyze SIRT6 expression in various cell types, providing valuable insights into its functions in aging, metabolism, and disease processes.SIRT6, a member of the sirtuin family of proteins, plays a crucial role in regulating gene expression, DNA repair, and glucose metabolism.
Dysregulation of SIRT6 has been implicated in various age-related diseases, including cancer, neurodegenerative disorders, and metabolic syndrome. By studying SIRT6 expression and activity, researchers can uncover novel therapeutic targets for these conditions and develop strategies to promote healthy aging and longevity.Overall, the SIRT6 Rabbit Monoclonal Antibody (CAB3591) is a valuable tool for investigating the role of SIRT6 in aging, metabolism, and disease, offering researchers a deeper understanding of the molecular mechanisms underlying these processes.
Product Name:
SIRT6 Rabbit Monoclonal Antibody
SKU:
CAB3591
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 256-355 of human SIRT6 (Q8N6T7).
This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
51548
Clone Number:
ARC0808
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using SIRT6 Rabbit mAb (CAB3591) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
