The SIRT6 Polyclonal Antibody is a valuable tool for researchers studying SIRT6, a critical protein involved in regulating various cellular processes, including DNA repair, metabolism, and aging. This antibody, produced in rabbits, is highly reactive with human samples and is validated for use in Western blot applications. By binding specifically to the SIRT6 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an ideal choice for studies in molecular biology, genomics, and aging research.SIRT6, a member of the sirtuin family of proteins, has been shown to play a key role in promoting longevity and protecting against age-related diseases, such as cancer, diabetes, and neurodegenerative disorders.
Understanding the function and activity of SIRT6 is essential for developing new therapies that target aging and age-related disorders. The SIRT6 Polyclonal Antibody provides researchers with a reliable tool for investigating the mechanisms underlying SIRT6 function and its potential as a therapeutic target in various diseases.
Product Name:
SIRT6 Polyclonal Antibody
SKU:
CAB21535
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 251-355 of human SIRT6 (NP_057623.2).
This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
51548
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using SIRT6 Rabbit pAb (CAB21535) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
